SML3801
Trospium chloride
≥98% (HPLC)
Synonym(s):
(1α,3β,5α)-3-[(hydroxydiphenylacetyl)oxy]spiro[8-azoniabicyclo[3.2.1]octane-8,1’-pyrrolidinium] chloride, Azoniaspiro(3α-benziloyloxynortropane-8,1′-pyrrolidine) chloride
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About This Item
Empirical Formula (Hill Notation):
C25H30NO3·Cl
CAS Number:
Molecular Weight:
427.96
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.21
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
InChI key
RVCSYOQWLPPAOA-QKYUOBHYNA-M
Biochem/physiol Actions
Peripheral muscarinic receptor antagonist
Trospium chloride is a peripheral muscarinic receptor antagonist that relaxes the smooth muscle in the bladder. It does ot cause central nervous system side effects typical for other drugs of its class. Trospium chloride is used for the treatment of overactive bladder.
Disclaimer
Hygroscopic
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Cognitive Effects of Anticholinergic Load in Women with Overactive Bladder
Clinical Interventions in Aging, 15, 1493-1503 (2020)
Kelly Biastre et al.
The Annals of pharmacotherapy, 43(2), 283-295 (2009-02-06)
To review the pharmacology, pharmacokinetics, safety, and clinical application of trospium chloride for the management of overactive bladder (OAB). Clinical literature including both primary sources and review articles was accessed through MEDLINE, International Pharmaceutical Abstracts, and Cochrane databases from 1980
Trospium chloride improves overactive bladder symptoms: a multicenter phase III trial
The Journal of Urology, 171(6 Pt 1), 2311-2315 (2004)
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