SML3866
SCR2682
≥98% (HPLC)
Synonym(s):
N-[4-(2-Bromo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2,6-dimethylphenyl]-3,3-dimethylbutanamide
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About This Item
Empirical Formula (Hill Notation):
C21H27BrN2OS
CAS Number:
Molecular Weight:
435.42
UNSPSC Code:
12352200
NACRES:
NA.21
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
room temp
Biochem/physiol Actions
Potent and selective opener of neuronal Kv7/KCNQ/M-channels that activates the native M-current in rat hippocampal or cortical neurons
SCR2682 is potent and selective opener of neuronal Kv7/KCNQ/M-channels that activates the native M-current in rat hippocampal or cortical neurons. It reverses epileptic seizures in rodents. SCR2682 relieves mechanical allodynia and thermal hyperalgesia in rat models of pain.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
Electrophysiological and pharmacological characterization of a novel and potent neuronal Kv7 channel opener SCR2682 for antiepilepsy
Faseb Journal, 33(8), 9154-9166 (2019)
Activation of Neuronal Voltage-Gated Potassium Kv7/KCNQ/M-Current by a Novel Channel Opener SCR2682 for Alleviation of Chronic Pain
Journal of Pharmacology and Experimental Therapeutics, 377(1), 20-28 (2021)
Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures
Journal of Pharmacology and Experimental Therapeutics, 384(2), 315-325 (2023)
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