SML3875
Usp22i-S02
≥98% (HPLC)
Synonym(s):
7,8,9,10-Tetrahydro-11-(phenylamino)benzimidazo[1,2-b]isoquinoline-6-carbonitrile, S02, USP22-IN-1
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About This Item
Empirical Formula (Hill Notation):
C22H18N4
CAS Number:
Molecular Weight:
338.41
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
Cell-permeable and potent inhibitor of ubiquitin specific peptidase 22 (USP22) that exhibits anticancer activity.
Usp22i-S02 is a cell-permeable benzimidazoisoquinoline-carbonitrile analog that is shown to reversibly occupy USP22 (ubiquitin specific peptidase 22) catalytic domain and suppress its functions. Usp22i-S02 arrests Usp22-mediated Foxp3 deubiquitination in iTREG cells in a time and dose-dependent manner. Usp22i-S02 administration enhances antitumor immunity with low toxicity in LLC1-challenged mice (20 mg/kg) and reduces tumor burden in a Treg-specific manner. immunity with low toxicity in LLC1-challenged mice (20 mg/kg) and reduces tumor burden in a Treg-specific manner.
Usp22i-S02 is a cell-permeable benzimidazoisoquinoline-carbonitrile analog that is shown to reversibly occupy USP22 (ubiquitin specific peptidase 22) catalytic domain and suppress its functions. Usp22i-S02 arrests Usp22-mediated Foxp3 deubiquitination in iTREG cells in a time and dose-dependent manner. Usp22i-S02 administration enhances antitumor immunity with low toxicity in LLC1-challenged mice (20 mg/kg) and reduces tumor burden in a Treg-specific manner. immunity with low toxicity in LLC1-challenged mice (20 mg/kg) and reduces tumor burden in a Treg-specific manner.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Elena Montauti et al.
Science advances, 8(47), eabo4116-eabo4116 (2022-11-26)
The tumor microenvironment (TME) enhances regulatory T (Treg) cell stability and immunosuppressive functions through up-regulation of lineage transcription factor Foxp3, a phenomenon known as Treg fitness or adaptation. Here, we characterize previously unknown TME-specific cellular and molecular mechanisms underlying Treg
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