SML3887
DS-5272
≥98% (HPLC)
Synonym(s):
DS 5272, [(2S,4R)-1-[[(5R,6S)-5-(4-Chloro-3-fluorophenyl)-6-(6-chloro-3-pyridinyl)-5,6-dihydro-6-methyl-3-(1-methylethyl)imidazo[2,1-b]thiazol-2-yl]carbonyl]-4-fluoro-2-pyrrolidinyl][(6R)-6-ethyl-4,7-diazaspiro[2.5]oct-7-yl]methanone
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About This Item
Empirical Formula (Hill Notation):
C34H38Cl2F2N6O2S
CAS Number:
Molecular Weight:
703.67
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Related Categories
Biochem/physiol Actions
Orally active and potent inhibitor of p53-MDM2 interaction.
DS-5272 is an orally active and potent inhibitor of p53-MDM2 interaction that exhibits efficacy against number of tumors including acute myeloid leukemia (AML). DS-5272 induces an immune-inflammatory response in MLL-AF9 cells.
DS-5272 is an orally active and potent inhibitor of p53-MDM2 interaction that exhibits efficacy against number of tumors including acute myeloid leukemia (AML). DS-5272 induces an immune-inflammatory response in MLL-AF9 cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Combined inhibition of MDM2 and BCR-ABL1 tyrosine kinase targets chronic myeloid leukemia stem/progenitor cells in a murine model
Haematologica, 105(5), 1274-1284 (2020)
Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated
Biochemical Pharmacology, 71(1-2), 13-20 (2005)
Discovery of DS-5272 as a promising candidate: A potent and orally active p53-MDM2 interaction inhibitor
Bioorganic & Medicinal Chemistry, 23(10), 2360-2367 (2015)
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