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SML3887

DS-5272

≥98% (HPLC)

Synonym(s):

DS 5272, [(2S,4R)-1-[[(5R,6S)-5-(4-Chloro-3-fluorophenyl)-6-(6-chloro-3-pyridinyl)-5,6-dihydro-6-methyl-3-(1-methylethyl)imidazo[2,1-b]thiazol-2-yl]carbonyl]-4-fluoro-2-pyrrolidinyl][(6R)-6-ethyl-4,7-diazaspiro[2.5]oct-7-yl]methanone

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About This Item

Empirical Formula (Hill Notation):
C34H38Cl2F2N6O2S
CAS Number:
Molecular Weight:
703.67
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

Orally active and potent inhibitor of p53-MDM2 interaction.
DS-5272 is an orally active and potent inhibitor of p53-MDM2 interaction that exhibits efficacy against number of tumors including acute myeloid leukemia (AML). DS-5272 induces an immune-inflammatory response in MLL-AF9 cells.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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