SML3889
NUCC-200823
≥98% (HPLC)
Synonym(s):
4,5,6,7-Tetrahydro-N-[[4-(1-piperidinyl)phenyl]methyl]-1-propyl-5-[[2-(4-pyridinyl)ethyl]amino]-1H-indazole-3-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C30H40N6O
CAS Number:
Molecular Weight:
500.68
NACRES:
NA.77
UNSPSC Code:
41116158
assay
≥98% (HPLC)
form
film or powder
color
, Almost Colorless
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
NUCC-200823 is potent and selective agonists for ACKR3 that competed effectively with CXCL12 for binding to ACKR3. NUCC-200823 does not activate CXCR4 or D2 receptors
Potent and selective agonists for ACKR3 that competed effectively with CXCL12 for binding to ACKR3
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Brittany E Hopkins et al.
Molecular pharmacology, 102(3), 128-138 (2022-07-10)
Chemokines such as stromal derived factor 1 and their G protein coupled receptors are well-known regulators of the development and functions of numerous tissues. C-X-C motif chemokine ligand 12 (CXCL12) has two receptors: C-X-C chemokine motif receptor 4 (CXCR4) and
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