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SML3898

P144 diammonium

≥95% (HPLC)

Synonym(s):

Disitertide diammonium, P144 diammonium, Peptide 144 diammonium, TSLDASIIWAMMQN diammonium, Thr-Ser-Leu-Asp-Ala-Ser-Ile-Ile-Trp-Ala-Met-Met-Gln-Asn diammonium

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About This Item

Empirical Formula (Hill Notation):
C68H109N17O22S2
Molecular Weight:
1580.82
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
(Powder or Lyophilized powder or film)
Storage condition:
desiccated
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Quality Segment

100

assay

≥95% (HPLC)

form

(Powder or Lyophilized powder or film)

storage condition

desiccated

color

white to off-white

storage temp.

-10 to -25°C

Biochem/physiol Actions

Human type 3 TGF-β receptor sequence-derived TGF-beta1 (TGF-β1) inhibitor that blocks TGF-β1-mediated responses in vitro and in vivo.


P144 (Disitertide) is a 14-aa peptide TGF-beta1 (TGF-β1) inhibitor whose sequence corresponds to aa731-744 of human type 3 TGF-β receptor (UniProt Q03167). P144 blocks TGF-β1 from binding the type 3 TGF-β receptor and inhibits TGF-β1-mediated responses in vitro (80% MV1Lu growth inhibition by 200 μg/mL P144 in the presence of 200 pg/mL human TGF-β1) and in vivo (57% inhibition of hepatic stellate cells (HSCs) activation in a rat model of CCl4 inhalation-induced cirrhosis/hepatic fibrosis; 70 μg P144/rat via q.o.d. i.p.).

Disclaimer

Hygroscopic

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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