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SML3898

P144 diammonium

new

≥95% (HPLC)

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Synonym(s):
Disitertide diammonium, P144 diammonium, Peptide 144 diammonium, TSLDASIIWAMMQN diammonium, Thr-Ser-Leu-Asp-Ala-Ser-Ile-Ile-Trp-Ala-Met-Met-Gln-Asn diammonium
Empirical Formula (Hill Notation):
C68H109N17O22S2
Molecular Weight:
1580.82

Quality Level

100

Assay

≥95% (HPLC)

form

(Powder or Lyophilized powder or film)

storage condition

desiccated

color

white to off-white

storage temp.

-10 to -25°C

Biochem/physiol Actions

Human type 3 TGF-β receptor sequence-derived TGF-beta1 (TGF-β1) inhibitor that blocks TGF-β1-mediated responses in vitro and in vivo.


P144 (Disitertide) is a 14-aa peptide TGF-beta1 (TGF-β1) inhibitor whose sequence corresponds to aa731-744 of human type 3 TGF-β receptor (UniProt Q03167). P144 blocks TGF-β1 from binding the type 3 TGF-β receptor and inhibits TGF-β1-mediated responses in vitro (80% MV1Lu growth inhibition by 200 μg/mL P144 in the presence of 200 pg/mL human TGF-β1) and in vivo (57% inhibition of hepatic stellate cells (HSCs) activation in a rat model of CCl4 inhalation-induced cirrhosis/hepatic fibrosis; 70 μg P144/rat via q.o.d. i.p.).

Caution

Hygroscopic

Regulatory Information

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Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis
The Journal of Investigative Dermatology, 125(3), 450-455 (2005)
Identification of peptide inhibitors of transforming growth factor beta 1 using a phage-displayed peptide library
Cytokine, 39(2), 106-115 (2007)
Peptide inhibitors of transforming growth factor-beta enhance the efficacy of antitumor immunotherapy
International Journal of Cancer. Journal International Du Cancer, 125(11), 2614-2623 (2009)
P144 a Transforming Growth Factor Beta Inhibitor Peptide, Generates Antifibrogenic Effects in a Radiotherapy Induced Fibrosis Model
Current Oncology (Toronto, Ont.), 29(4), 2650-2661 (2022)
A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury
Cytokine, 22(1-2), 12-20 (2003)
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