SML3940
KNX-002
≥98% (HPLC)
Synonym(s):
N-[1-(4-Methoxyphenyl)cyclopropyl]-3-(2-thienyl)-1H-pyrazole-4-methanamine
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About This Item
Empirical Formula (Hill Notation):
C18H19N3OS
CAS Number:
Molecular Weight:
325.43
UNSPSC Code:
12352200
NACRES:
NA.21
InChI
1S/C18H19N3OS/c1-22-15-6-4-14(5-7-15)18(8-9-18)19-11-13-12-20-21-17(13)16-3-2-10-23-16/h2-7,10,12,19H,8-9,11H2,1H3,(H,20,21)
InChI key
CXRMCTBDMZVPNE-UHFFFAOYSA-N
SMILES string
COC1=CC=C(C2(CC2)NCC3=CNN=C3C4=CC=CS4)C=C1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Cell penetrant, potent and selective inhibitor of Plasmodium falciparum myosin A (PfMyoA) and Toxoplasma gondii myosin A (TgMyoA).
KNX-002 is a cell penetrant, potent and selective inhibitor of Plasmodium falciparum myosin A (PfMyoA) and Toxoplasma gondii myosin A (TgMyoA) that has no or little effect on the vertebrate myosins tested. KNX-002 obstructs efficient ATP hydrolysis thus inhibiting motor activity. KNX-002 inhibits parasite motility and growth.
KNX-002 is a cell penetrant, potent and selective inhibitor of Plasmodium falciparum myosin A (PfMyoA) and Toxoplasma gondii myosin A (TgMyoA) that has no or little effect on the vertebrate myosins tested. KNX-002 obstructs efficient ATP hydrolysis thus inhibiting motor activity. KNX-002 inhibits parasite motility and growth.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Anne Kelsen et al.
PLoS biology, 21(5), e3002110-e3002110 (2023-05-08)
Toxoplasma gondii is a widespread apicomplexan parasite that can cause severe disease in its human hosts. The ability of T. gondii and other apicomplexan parasites to invade into, egress from, and move between cells of the hosts they infect is
Dihia Moussaoui et al.
Nature communications, 14(1), 3463-3463 (2023-06-13)
Malaria results in more than 500,000 deaths per year and the causative Plasmodium parasites continue to develop resistance to all known agents, including different antimalarial combinations. The class XIV myosin motor PfMyoA is part of a core macromolecular complex called
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