SML4002
SGC-CAF382-1
≥98% (HPLC)
Synonym(s):
CAF 382, CAF 382 (B1), CAF-382, CAF-382 (B1), CAF382, CAF382 (B1), N-(5-(((5-Isopropyloxazol-2-yl)methyl)thio)thiazol-2-yl)piperidine-4-carboxamide 2,2,2-trifluoroacetate
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(NC1=NC=C(S1)SCC2=NC=C(O2)C(C)C)C3CCNCC3.[xTFA]
Related Categories
Biochem/physiol Actions
Potent cyclin-dependent kinase-like 5 inhibitor with additional potency against CDK9/16/17/18 and good kinome-wide selectivity.
SGC-CAF382-1 is a potent cyclin-dependent kinase-like 5 inhibitor (CDKL5 IC50 = 6.7 nM by binding assay & 10 nM by cellular NanoBRET) with additional potency against CDK9/16/17/18 (IC50 = 20/62/89/100 nM by cell-free enzymatic assay, 280/390/240/260 nM by cellular NanoBRET) and good kinome-wide selectivity. SGC-CAF382-1 downregulates EB2 Ser222 phosphorylation in DIV14-16 rat primary neurons (IC50 <5 nM) and in hippocampal slices from P20–30 rats ex vivo (IC50 <45 nM).
SGC-CAF382-1 is a potent cyclin-dependent kinase-like 5 inhibitor (CDKL5 IC50 = 6.7 nM by binding assay & 10 nM by cellular NanoBRET) with additional potency against CDK9/16/17/18 (IC50 = 20/62/89/100 nM by cell-free enzymatic assay, 280/390/240/260 nM by cellular NanoBRET) and good kinome-wide selectivity. SGC-CAF382-1 downregulates EB2 Ser222 phosphorylation in DIV14-16 rat primary neurons (IC50 <5 nM) and in hippocampal slices from P20–30 rats ex vivo (IC50 <45 nM).
Disclaimer
Hygroscopic
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Anna Castano et al.
eLife, 12 (2023-07-25)
Pathological loss-of-function mutations in cyclin-dependent kinase-like 5 (CDKL5) cause CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental disorder associated with severe and medically refractory early-life epilepsy, motor, cognitive, visual, and autonomic disturbances in the absence of any structural brain
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service