SML4037
ASP7967
≥98% (HPLC)
Synonym(s):
N2,N4-bis(4-Fluorophenyl)-N6-(2-pyrimidinylmethyl)-1,3,5-triazine-2,4,6-triamine
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C20H16F2N8
CAS Number:
Molecular Weight:
406.39
UNSPSC Code:
41106305
NACRES:
NA.21
InChI key
UAAKDZMQDFXQTN-UHFFFAOYSA-N
SMILES string
FC1=CC=C(NC2=NC(NCC3=NC=CC=N3)=NC(NC4=CC=C(C=C4)F)=N2)C=C1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable, low-toxic triazine-triamine ligand of the RNA aptamer AC17-4 that effectively activates gene expression in riboswitches and significantly raises hEPO levels in mice.
ASP7967 is a cell permeable, low-toxic triazine-triamine ligand of the RNA aptamer AC17-4 with a Kd of 12 nM and an EC50 of 2.3 µM. ASP-7967 significantly activates gene expression in aptazyme-based riboswitches, exceeding a tenfold increase in HEK293 cells. Furthermore, when administered orally at 100 mg/kg, ASP 7967 substantially boosts serum human erythropoietin (hEPO) levels in mice, about 7.2 times more than the control, demonstrating its robust in vivo effectiveness.
ASP7967 is a cell permeable, low-toxic triazine-triamine ligand of the RNA aptamer AC17-4 with a Kd of 12 nM and an EC50 of 2.3 µM. ASP-7967 significantly activates gene expression in aptazyme-based riboswitches, exceeding a tenfold increase in HEK293 cells. Furthermore, when administered orally at 100 mg/kg, ASP 7967 substantially boosts serum human erythropoietin (hEPO) levels in mice, about 7.2 times more than the control, demonstrating its robust in vivo effectiveness.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Keisuke Fukunaga et al.
Journal of the American Chemical Society, 145(14), 7820-7828 (2023-03-31)
Synthetic riboswitches that can regulate gene expression by a small molecule recognized by an RNA aptamer in mammalian cells have various potential applications in biotechnology and medicine. However, the variety of small molecules and their cognate aptamers that have been
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service