Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
ML-T7 is a selective T-cell immunoglobulin and mucin domain-containing proteins TIM-3/4 inhibitor that targets the FG-CC′ cleft involved in PtdSer and CEACAM1 binding (h/mTIM-3 Kd = 6.98/7.40 μM, hTIM-4 Kd = 11.98 μM). ML-T7 promotes the activity of nature killer (NK) cells, the antigen-presenting capacity of dendric cells (DCs), the survival and antitumor activity of primary CD8+ cytotoxic T lymphocytes (CTLs) and chimeric antigen receptor (CAR) T cells (5-10 μM). ML-T7 exerts antitumor activity and potentiates anti-PD-1 therapy in a spontaneous orthotopic hepatocellular carcinoma (HCC) model in mice in vivo (20 mg/kg, q.o.d. i.p.).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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