SML4051
ML-T7
≥98% (HPLC)
Synonym(s):
5-(2,4-Dichlorophenyl)-3-(p-tolyl)-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2′-indene]-1′,3′,4,6(3H,5H)-tetraone, 5-(2,4-Dichlorophenyl)-1-(4-methylphenyl)-3a,6a-dihydrosprio[1H-furo[3,4-c]pyrrole-3,20-(10H)-indene]-10,30,4,6(20H,3H,5H)-tetrone
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About This Item
Empirical Formula (Hill Notation):
C27H17Cl2NO5
CAS Number:
Molecular Weight:
506.33
UNSPSC Code:
12352200
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
ML-T7 is a selective T-cell immunoglobulin and mucin domain-containing proteins TIM-3/4 inhibitor that targets the FG-CC′ cleft involved in PtdSer and CEACAM1 binding (h/mTIM-3 Kd = 6.98/7.40 μM, hTIM-4 Kd = 11.98 μM). ML-T7 promotes the activity of nature killer (NK) cells, the antigen-presenting capacity of dendric cells (DCs), the survival and antitumor activity of primary CD8+ cytotoxic T lymphocytes (CTLs) and chimeric antigen receptor (CAR) T cells (5-10 μM). ML-T7 exerts antitumor activity and potentiates anti-PD-1 therapy in a spontaneous orthotopic hepatocellular carcinoma (HCC) model in mice in vivo (20 mg/kg, q.o.d. i.p.).
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