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Merck
CN

SML4063

Abz-SVTLQSG-TyrNO2R trifluoroacetate

≥95% (HPLC)

Synonym(s):

N-(2-Aminobenzoyl)-L-seryl-L-valyl-L-threonyl-L-leucyl-L-glutaminyl-L-serylglycyl-2-nitro-L-tyrosyl-L-arginine trifluoroacetate, 2-Aminobenzoyl-Ser-Val-Thr-Leu-Gln-Ser-Gly-Tyr(NO2)R trifluoroacetate, Abz-SVTLQSG-Tyr(NO2)R trifluoroacetate, Abz-Ser-Val-Thr-Leu-Gln-Ser-Gly-Tyr(NO2)R trifluoroacetate

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About This Item

Empirical Formula (Hill Notation):
C50H75N15O18 · xC2HF3O2
Molecular Weight:
1174.22 (free base basis)
NACRES:
NA.28
Assay:
≥95% (HPLC)
Form:
(Powder or Lyophilized powder or film)
Quality level:
100
Storage condition:
desiccated

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SMILES string

N=C(NCCC[C@H](NC([C@H](CC1=C(C=C(O)C=C1)[N+]([O-])=O)NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C2=C(N)C=CC=C2)=O)CO)=O)C(C)C)=O)[C@@H](C)O)=O)CC(C)C)=O)CCC(N)=O)=O)CO)=O)=O)=O)C(O)=O)N

assay

≥95% (HPLC)

form

(Powder or Lyophilized powder or film)

storage condition

desiccated

color

, White to light brown

storage temp.

-10 to -25°C

Quality Level

100

Biochem/physiol Actions

SARS-CoV and SARS-CoV-2 main protease (Mpro; 3CLpro) fluorescence energy transfer (FRET) substrate with >10-fold sensitivity than Edans-Dabcyl-based substrate.

Abz-SVTLQSG-TyrNO2R (Abz = 2-aminobenzoyl; TyrNO2 = 2-nitro-L-tyrosyl) is a substrate for the detection of SARS-CoV and SARS-CoV-2 main protease (Mpro; 3CLpro) activity by fluorescence energy transfer (FRET) with >10-fold sensitivity than the corresponding Edans-Dabcyl-based FRET peptide. Substrate cleavage by Mpro between Gln and Ser leads to increased fluorescence (ex 330+/-10 nm, em 420+/-20 nm) as a result of the separation of the N-terminal Abz (fluorescent donor) and the C-terminal TyrNO2 (fluorescent quencher).

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Certificates of Analysis (COA)

Lot/Batch Number
0000423803
0000423804
0000423803
0000423804
0000401107

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