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About This Item
Empirical Formula (Hill Notation):
C50H75N15O18 · xC2HF3O2
Molecular Weight:
1174.22 (free base basis)
NACRES:
NA.28
Assay:
≥95% (HPLC)
Form:
(Powder or Lyophilized powder or film)
Quality level:
Storage condition:
desiccated
Quality Level
assay
≥95% (HPLC)
form
(Powder or Lyophilized powder or film)
storage condition
desiccated
color
, White to light brown
storage temp.
-10 to -25°C
SMILES string
N=C(NCCC[C@H](NC([C@H](CC1=C(C=C(O)C=C1)[N+]([O-])=O)NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C2=C(N)C=CC=C2)=O)CO)=O)C(C)C)=O)[C@@H](C)O)=O)CC(C)C)=O)CCC(N)=O)=O)CO)=O)=O)=O)C(O)=O)N
Biochem/physiol Actions
SARS-CoV and SARS-CoV-2 main protease (Mpro; 3CLpro) fluorescence energy transfer (FRET) substrate with >10-fold sensitivity than Edans-Dabcyl-based substrate.
Abz-SVTLQSG-TyrNO2R (Abz = 2-aminobenzoyl; TyrNO2 = 2-nitro-L-tyrosyl) is a substrate for the detection of SARS-CoV and SARS-CoV-2 main protease (Mpro; 3CLpro) activity by fluorescence energy transfer (FRET) with >10-fold sensitivity than the corresponding Edans-Dabcyl-based FRET peptide. Substrate cleavage by Mpro between Gln and Ser leads to increased fluorescence (ex 330+/-10 nm, em 420+/-20 nm) as a result of the separation of the N-terminal Abz (fluorescent donor) and the C-terminal TyrNO2 (fluorescent quencher).
Abz-SVTLQSG-TyrNO2R (Abz = 2-aminobenzoyl; TyrNO2 = 2-nitro-L-tyrosyl) is a substrate for the detection of SARS-CoV and SARS-CoV-2 main protease (Mpro; 3CLpro) activity by fluorescence energy transfer (FRET) with >10-fold sensitivity than the corresponding Edans-Dabcyl-based FRET peptide. Substrate cleavage by Mpro between Gln and Ser leads to increased fluorescence (ex 330+/-10 nm, em 420+/-20 nm) as a result of the separation of the N-terminal Abz (fluorescent donor) and the C-terminal TyrNO2 (fluorescent quencher).
Disclaimer
Hygroscopic
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML4063-1MG | 04065272053501 |
| SML4063-5MG | 04065272053617 |
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