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About This Item
Empirical Formula (Hill Notation):
C19H16ClN5OS
CAS Number:
Molecular Weight:
397.88
MDL number:
NACRES:
NA.21
Assay:
≥97% (HPLC)
Form:
powder
Quality Segment
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
ClC1=CN=C(N)N=C1N2C3=CC(C#CC(C4=NC=CS4)(C)O)=CC=C3CC2
Biochem/physiol Actions
Potent and selective NF-κB-inducing kinase (NIK) inhibitor that selectively disrupts NF-κB activation in cultures and in vivo.
B022 is an ATP site-targeting, potent and selective NF-κB-inducing kinase (NIK) inhibitor (Ki = 5 nM against 5 μM ATP using mouse NIK) that inhibits NIK-induced p100-to-p52 processing (IC50 <0.5 μM; Hepa1 cells overexpressing p100 & NIK) and NF-κB2 activity (by 38% by 0.5 μM and 96% by 5 μM B022; HEK293 NIK transfectant with NF-κB reporter plasmid). B022 protects mice from death due to liver-specific NIK overexpression in mice in vivo (30 mg/kg via b.i.d.tail vein injection).
B022 is an ATP site-targeting, potent and selective NF-κB-inducing kinase (NIK) inhibitor (Ki = 5 nM against 5 μM ATP using mouse NIK) that inhibits NIK-induced p100-to-p52 processing (IC50 <0.5 μM; Hepa1 cells overexpressing p100 & NIK) and NF-κB2 activity (by 38% by 0.5 μM and 96% by 5 μM B022; HEK293 NIK transfectant with NF-κB reporter plasmid). B022 protects mice from death due to liver-specific NIK overexpression in mice in vivo (30 mg/kg via b.i.d.tail vein injection).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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