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Merck
CN

SML4161

Enrofloxacin hydrochloride

≥98% (HPLC), powder, Fluoroquinolone antibiotic

Synonym(s):

1-Cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride, Enrofloxacin HCl

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About This Item

Empirical Formula (Hill Notation):
C19H22FN3O3.HCl
CAS Number:
Molecular Weight:
395.86
MDL number:
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
Storage condition:
desiccated
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SMILES string

OC(C1=CN(C2CC2)C3=CC(N4CCN(CC)CC4)=C(F)C=C3C1=O)=O.Cl

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

Quality Level

Application

Enrofloxacin hydrochloride may be used in studies assessing the presence of enrofloxacin in water sources, contributing to environmental safety and pollution control. It may also be used in analytical methods for detecting enrofloxacin residues in food products, ensuring compliance with safety regulations.

Biochem/physiol Actions

Enrofloxacin hydrochloride is a fluoroquinolone antibiotic with broad-spectrum activity, which kills bacteria by blocking DNA gyrase and type IV topoisomerase interaction with DNA. This antibiotic belongs to the fluoroquinolone group, specifically the 6-fluoro-7-piperazinyl-4-quinolones. Enrofloxacin hydrochloride is effective against both Gram-negative and Gram-positive bacteria. It is commonly used in veterinary medicine. Enrofloxacin HCl exhibits better water solubility than enrofloxacin.

Regulatory Information

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Sicong Qiao et al.
Journal of medicinal chemistry, 68(14), 14312-14332 (2025-05-09)
Aging induces dysfunction and increases the risk of chronic diseases in the elderly, positioning the development of antiaging drugs to the forefront of research. Drug repurposing offers an efficient strategy for identifying antiaging lead compounds. In this study, we employed
Enrofloxacin?The Ruthless Killer of Eukaryotic Cells or the Last Hope in the Fight against Bacterial Infections?
Grabowski L, et al.
International Journal of Molecular Sciences, 23 (2022)

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