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About This Item
Empirical Formula (Hill Notation):
C16H28O7P2
CAS Number:
Molecular Weight:
394.34
MDL number:
NACRES:
NA.21
Assay:
≥90% (HPLC)
Form:
powder
Quality Segment
assay
≥90% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
O=P(O)(C(P(O)(O)=O)CC1=CC(OCCCCCCCC)=CC=C1)O
Application
TH-Z145 may be used as a research tool in studies investigating the mevalonate pathway and its implications in various biological processes, including cancer and inflammation. It may also be used as a potent vaccine adjuvant to enhance immune responses by targeting the mevalonate pathway to improve the efficacy of vaccines.
Biochem/physiol Actions
Potent and selective mevalonate (MVA) pathway geranylgeranyl diphosphate synthase (GGPPS) inhibitor that stimulates immune responses in vivo.
TH-Z145 is a potent and selective geranylgeranyl diphosphate synthase (GGPPS) inhibitor (IC50 = 210 nM; FPPS IC50 > 30 µM) that stimulates immune responses by blocking the mevalonate (MVA) pathway-mediated post-translational protein geranylgeranylation. When co-administered with antigen in mice in vivo, TH-Z145 triggers strong adjuvant responses, increasing OVA-specific antibody titres (in mice immunized with 100 μg OVA + 100 μg TH-Z145) and protecting against death caused by live influenza virus PR8 challenge (in mice immunized with 5 μg PR8 HA1 subunit containing TH-Z145). TH-Z145 adjuvant efficacy is blocked by GGPP and synergized with HMG-CoA inhibitor simvastatin.
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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