Key Documents

View All Documentation

SML4179

Seladelpar

Name: Seladelpar
Brand: SIGMA

≥98% (HPLC), (liquid, semi-solid, solid or powder), PPARδ agonist

Synonym(s):

2-[4-[[(2R)-2-Ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]thio]-2-methylphenoxy]acetic acid, (R)-(4-(2-Ethoxy-3-(4-trifluoromethyl-phenoxy)-propylsulfanyl)-2-methyl-phenoxy)acetic acid, MBX 8025, MBX-8025, MBX8025, RWJ 800025, RWJ-800025, RWJ800025

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₃F₃O₅S

CAS Number:

851528-79-5

Molecular Weight:

444.46

MDL number:

MFCD28502443

NACRES:

NA.21

Assay:

≥98% (HPLC)

Form:

(liquid, semi-solid, solid or powder)

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Segment

100

assay

≥98% (HPLC)

form

(liquid, semi-solid, solid or powder)

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(COC1=C(C=C(C=C1)SC[C@H](OCC)COC2=CC=C(C=C2)C(F)(F)F)C)=O

Description

Application

Seladelpar has been used as a PPARδ agonist to study its role in reducing bile acid synthesis in hepatocytes.

Biochem/physiol Actions

Seladelpar (MBX-8025) is an orally active, potent and selective Peroxisome proliferator–activated receptor delta (PPAR-δ) agonist (EC50 = 2 nM post 24h treatment using HEK293 PPARβ/δ reporter cells) with >750- and >2500-fold higher potency over that of PPAR-α and PPAR-γ, respectively. Seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice in vivo (10 mg/kg/d via liquid diet). Seladelpar plays a significant role in regulating bile acid metabolism and inflammation. By activating PPARδ, seladelpar promotes fatty acid oxidation and reduces lipid accumulation in the liver, which is predominantly observed in primary biliary cholangitis (PBC) and non-alcoholic steatohepatitis (NASH). PPARδ activation also results in the downregulation of bile acid synthesis by reducing the expression of cholesterol 7 alpha-hydroxylase (CYP7A1), a key enzyme in bile acid synthesis. Seladelpar also enhances the signaling of fibroblast growth factor 21 (FGF21), contributing to its anti-inflammatory effects.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library