SML4181
Sulbactam sodium
≥98% (HPLC), powder, β-lactamase inhibitor
Synonym(s):
CP 45899-2, Sodium (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide, (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide sodium salt, Penicillanic acid 1,1-dioxide sodium salt, Sodium 1,1-dioxypenicillanate, Sodium penicillanate 1,1-dioxide
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About This Item
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
O=C([C@@H]1N2[C@]([H])(S(=O)(C1(C)C)=O)CC2=O)O[Na]
Application
Biochem/physiol Actions
Sulbactam sodium, the sodium salt form of sulbactam, is water-soluble and exhibits enhanced hydrophilicity and is better suited for formulations involving aqueous media. In its capacity as a β-lactamase inhibitor, sulbactam sodium synergistically augments the antimicrobial efficacy of β-lactam antibiotics against recalcitrant bacterial pathogens. This synergistic effect is achieved through an irreversible covalent interaction between sulbactam and the β-lactamase enzymes, which are responsible for the degradation and consequent inactivation of β-lactam antibiotics. Additionally, sulbactam sodium demonstrates inherent antibacterial activity, albeit with a relatively lower potency compared to other members of the β-lactam antibiotic class.
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