SML4186
Levofloxacin hydrochloride
≥98% (HPLC), powder, DNA gyrase and topoisomerase IV inhibitor
Sign Into View Organizational & Contract Pricing
Select a Size
About This Item
Empirical Formula (Hill Notation):
C18H20FN3O4 · xHCl
CAS Number:
Molecular Weight:
361.37 (free base basis)
MDL number:
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
O=C1C2=CC(F)=C(C3=C2N([C@H](CO3)C)C=C1C(O)=O)N4CCN(C)CC4.[xHCl]
General description
Levofloxacin is the L-isomer of the racemic fluoroquinolone, ofloxacin. It has a more intricate fused ring structure that is linked to the oxazinoquinoline core as compared to quinolones. Levofloxacin is a broad-spectrum fluoroquinolone antibiotic that exhibits high water solubility. While the hydrochloride form of levofloxacin is freely soluble in water, levofloxacin itself is only sparingly soluble in aqueous solutions.
Application
Levofloxacin hydrochloride may be used to:
- investigate its antibacterial effects against Gram-positive and Gram-negative bacteria
- assess environmental antibiotic pollution
- study drug–food interactions in pharmacokinetic research by evaluating the impact of dietary interventions on quinolone bioavailability
Biochem/physiol Actions
Levofloxacin is a fluoroquinolone antibiotic with broad-spectrum activity, the optical S-(-) isomer of ofloxacin, which kills bacteria by blocking DNA gyrase and type IV topoisomerase—critical enzymes for DNA replication and transcription—leading to cell death. It is effective against a broad array of both Gram-positive and Gram-negative bacteria, in addition to Mycoplasmas.
Disclaimer
Hygroscopic Store with desiccant
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Agnieszka Wiesner et al.
Clinical pharmacokinetics, 63(6), 773-818 (2024-05-29)
Managing drug-food interactions is essential for optimizing the effectiveness and safety profile of quinolones. Following PRISMA guidelines, we systematically reviewed the influence of dietary interventions on the bioavailability of 22 quinolones. All studies describing or investigating the impact of food
Levofloxacin, a new quinolone antibacterial agent. An introductory overview.
I Hayakawa et al.
Arzneimittel-Forschung, 43(3A), 363-364 (1992-03-01)
Raizza Zorman Marques et al.
Environmental pollution (Barking, Essex : 1987), 357, 124376-124376 (2024-06-20)
We compared the ability of one emergent (Sagittaria montevidensis), two floating (Salvinia minima and Lemna gibba), and one heterophyllous species (Myriophyllum aquaticum) to simultaneously remove sulfamethoxazole, sulfadiazine, ciprofloxacin, enrofloxacin, norfloxacin, levofloxacin, oxytetracycline, tetracycline, doxycycline, azithromycin, amoxicillin, and meropenem from wastewater
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service