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About This Item
Empirical Formula (Hill Notation):
C15H14N2O2S2
CAS Number:
Molecular Weight:
318.41
MDL number:
NACRES:
NA.21
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Application
E17241 may be used to explore its impact on liver steatosis and adipose tissue inflammation in high-fat/high-glucose-fed mice by analyzing histological changes and gene expression profiling; to assess its cardiorenal protective effects in diabetic nephropathy and cardiomyopathy models through tissue morphology and biochemical markers.
Biochem/physiol Actions
E17241 is an orally active pan-PPAR agonist (EC50 in µM = 0.29/γ, 0.88/δ(β), 3.9/α in HepG2 reporter cells) that upregulates PPAR target genes expression (ABCA1 EC50 = 626.9 nM in HepG2 reporter cells). E17241 boosts ABCA1-dependent cholesterol efflux and insulin secretion in INS-1 rat insulinoma cultures (20 nM to 10 µM) and exhibits therapeutic efficacy in diabetic mice in vivo (50 mg/kg via daily p.o.).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1B
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Yanni Xu (许艳妮) et al.
Arteriosclerosis, thrombosis, and vascular biology, 41(6), e284-e298 (2021-01-15)
[Figure: see text].
Ren Sheng et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 172, 116220-116220 (2024-02-04)
Type 2 diabetes mellitus (T2DM) is a common chronic metabolic disease. Peroxisome proliferator-activated receptors (PPARs) play crucial roles in regulating glucolipid metabolism. Previous studies showed that E17241 could ameliorate atherosclerosis and lower fasting blood glucose levels in ApoE-/- mice. In
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML4188-50MG | 04065272725545 |
| SML4188-10MG | 04065272725538 |