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About This Item
Empirical Formula (Hill Notation):
C18H20FN3O4 · xHCl
CAS Number:
Molecular Weight:
361.37 (free base basis)
MDL number:
NACRES:
NA.21
SMILES string
O=C(O)C1=CN2C3=C(OCC2C)C(N4CCN(C)CC4)=C(F)C=C3C1=O.[xHCl]
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
-10 to -25°C
General description
Ofloxacinhydrochloride is a broad-spectrum fluoroquinolone antibiotic that exhibitswater solubility, whereas ofloxacin itself is only sparingly soluble in aqueoussolutions.
Application
Ofloxacin hydrochloride may be used as a standard to study theadsorption behaviour of antibiotics.
Biochem/physiol Actions
Ofloxacin kills bacteria by blocking DNA gyrase and type IV topoisomerase—critical enzymes for DNA replication and transcription—leading to cell death. Ofloxacin has 100 times higher affinity for bacterial DNA gyrase than for mammalian. It is effective against a broad array of both Gram-positive and Gram-negative bacteria, in addition to Mycoplasmas.
Disclaimer
Hygroscopic Store with desiccant
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Yaping Wu et al.
Journal of global antimicrobial resistance, 36, 13-25 (2023-11-29)
Mycoplasma and Ureaplasma spp. especially M. hominis, U. parvum, and U. urealyticum recognized as an important cause of urogenital infections. Sake of the presence of antibiotic resistance and a continuous rise in resistance, the treatment options are limited, and treatment
K Sato et al.
Antimicrobial agents and chemotherapy, 22(4), 548-553 (1982-10-01)
DL-8280, 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H- pyrido-(1,2,3-de)1,4-benzoxazine-6-carboxylic acid, is a new nalidixic acid analog with a broad spectrum of antibacterial activity against gram-negative and gram-positive bacteria, including obligate anaerobes. The activity of DL-8280 against Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, and Clostridium perfringens
Ab Raouf Bhat et al.
International journal of biological macromolecules, 274(Pt 1), 133011-133011 (2024-06-10)
Human serum albumin (HSA) effectively binds to compounds having different molecular weight and thus facilitates their distribution in the living organisms. Thus, the binding interactions between a potential antibacterial drug (levofloxacin) and synthesized choline based levofloxacinate conjugates with HSA have
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