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Merck
CN

SML4221

Ofloxacin hydrochloride

new

≥98% (HPLC)

Synonym(s):

9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hydrochloride, (±)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hydrochloride, Ofloxacin HCl

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About This Item

Empirical Formula (Hill Notation):
C18H20FN3O4 · xHCl
CAS Number:
118120-51-7
Molecular Weight:
361.37 (free base basis)
MDL number:
MFCD00226105

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

O=C(O)C1=CN2C3=C(OCC2C)C(N4CCN(C)CC4)=C(F)C=C3C1=O.[xHCl]

Biochem/physiol Actions

Broad-spectrum fluoroquinolone antibiotic, exhibits water solubility.
Ofloxacin is a fluoroquinolone antibiotic with broad-spectrum activity, which kills bacteria by blocking DNA gyrase and type IV topoisomerase—critical enzymes for DNA replication and transcription—leading to cell death. Ofloxacin has 100 times higher affinity for bacterial DNA gyrase than for mammalian. It is effective against a broad array of both Gram-positive and Gram-negative bacteria, in addition to Mycoplasmas. While the hydrochloride form of ofloxacin is soluble in water, ofloxacin itself is only sparingly soluble in aqueous solutions.

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Certificates of Analysis (COA)

Lot/Batch Number
0000462057
0000462057

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Yaping Wu et al.
Journal of global antimicrobial resistance, 36, 13-25 (2023-11-29)
Mycoplasma and Ureaplasma spp. especially M. hominis, U. parvum, and U. urealyticum recognized as an important cause of urogenital infections. Sake of the presence of antibiotic resistance and a continuous rise in resistance, the treatment options are limited, and treatment
Ab Raouf Bhat et al.
International journal of biological macromolecules, 274(Pt 1), 133011-133011 (2024-06-10)
Human serum albumin (HSA) effectively binds to compounds having different molecular weight and thus facilitates their distribution in the living organisms. Thus, the binding interactions between a potential antibacterial drug (levofloxacin) and synthesized choline based levofloxacinate conjugates with HSA have
K Sato et al.
Antimicrobial agents and chemotherapy, 22(4), 548-553 (1982-10-01)
DL-8280, 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H- pyrido-(1,2,3-de)1,4-benzoxazine-6-carboxylic acid, is a new nalidixic acid analog with a broad spectrum of antibacterial activity against gram-negative and gram-positive bacteria, including obligate anaerobes. The activity of DL-8280 against Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, and Clostridium perfringens

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