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SML4222

Eribulin

≥98% (HPLC), powder, microtubule dynamics inhibitor

Synonym(s):

2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy- 26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy- 7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2′,3′-5,6) pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one

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About This Item

Empirical Formula (Hill Notation):
C40H59NO11
CAS Number:
253128-41-5
Molecular Weight:
729.90
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

General description

Eribulin is a synthetic analog of Halichondrin B, a compound isolated from the sea sponge Halichondria okadai.

Application

Eribulin may be used for investigating its effects on tumor microenvironment and tumor vasculature.

Biochem/physiol Actions

Eribulin is a microtubule dynamics inhibitor that results in prolonged mitotic arrest and subsequent apoptosis. It suppresses microtubule dynamic instability at plus ends through an inhibition of microtubule growth with little or no effect on shortening. Eribulin displays anticancer activity by inhibiting the proliferation of multiple cancer cell types.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

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