SML4222
Eribulin
≥98% (HPLC)
Synonym(s):
2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy- 26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy- 7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2′,3′-5,6) pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one
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About This Item
Empirical Formula (Hill Notation):
C40H59NO11
CAS Number:
Molecular Weight:
729.90
UNSPSC Code:
12352200
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
General description
Microtubule dynamics inhibitor with anticancer activity.
Eribulin is a synthetic analog of Halichondrin B, a compound isolated from the sea sponge Halichondria okadai. It is a microtubule dynamics inhibitor that results in prolonged mitotic arrest and subsequent apoptosis. Eribulin suppresses microtubule dynamic instability at plus ends through an inhibition of microtubule growth with little or no effect on shortening. Eribulin inhibits the proliferation of multiple cancer cell types.
Eribulin is a synthetic analog of Halichondrin B, a compound isolated from the sea sponge Halichondria okadai. It is a microtubule dynamics inhibitor that results in prolonged mitotic arrest and subsequent apoptosis. Eribulin suppresses microtubule dynamic instability at plus ends through an inhibition of microtubule growth with little or no effect on shortening. Eribulin inhibits the proliferation of multiple cancer cell types.
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Javier Cortes et al.
Cancer treatment reviews, 70, 190-198 (2018-09-23)
Eribulin mesylate (eribulin) is a synthetic analogue of the marine-sponge natural product halichondrin B. Eribulin exhibits potent antiproliferative activities against a variety of human cancer cell types in vitro and in vivo, and is used for the treatment of certain
Ornella Garrone et al.
Future oncology (London, England), 13(30), 2759-2769 (2017-12-09)
Eribulin is a synthetic analog of halichondrin B belonging to microtubule-targeted agents with a distinct mechanism of inhibition of microtubule dynamics. This molecule has multiple nonmitotic effects on tumor biology, exhibiting effects on epithelial-mesenchimal transition and tumor vasculature. We review
Panagiotis Koliou et al.
Cancer management and research, 10, 207-216 (2018-02-15)
Eribulin mesylate is a synthetic derivative of halichondrin B isolated from a marine sponge. Its mechanism of action is through microtubule inhibition, which is different from that of taxanes. Eribulin has been approved for the treatment of metastatic breast cancer
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