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SML4234

Nek1 Inhibitor 10f

Name: Nek1 Inhibitor 10f
Brand: SIGMA

≥98% (HPLC), powder, NIMA Related Kinase 1 inhibitor

Synonym(s):

(R)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide, Nek1i-10f, NIMA-related kinase 1 Inhibitor 10f

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₂₂N₄O₃S

CAS Number:

2727158-07-6

Molecular Weight:

446.52

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Description

Application

Nek1 Inhibitor 10f may be used to analyze the effects of NEK1 inhibition on ciliogenesis in zebrafish pronephros. It may also be used to evaluate its efficacy, toxicity, and bioavailability in models of zebrafish polycystic kidney disease.

Biochem/physiol Actions

Nek1 Inhibitor 10f (Nek1i-10f) is a cell-permeable azaindolo-D-tryptophanyl compound that acts as a potent and ATP-competitive Nek1 selective inhibitor (IC50 at 10 µM ATP = 330 nM; 96% inhibition at 1 µM). Nek1 Inhibitor 10f is shown to dominantly affect IKKb activity in a 50-kinase panel. Nek1i-10f is bioavailable, highly efficacious with less toxicity and causes cystic kidneys in zebrafish embryos (10 µM). Nek1-IN-10f reduces NEK1 levels and perturbs nucleocytoplasmic transport in induced pluripotent stem cell motor neurons.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Global Trade Item Number

SKU	GTIN
SML4234-25MG	04065273262360
SML4234-5MG	04065273262377