Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Application
GSK0660 may be used in cell viability assay, real time cell index analysis, and oxyblot assays to study its neuroprotective effect on Parkinson’s disease model in vivo and in vitro.
Biochem/physiol Actions
GSK0660 is a potent and selective peroxisome proliferator-activated receptor delta (PPARdelta) and PPARbeta antagonist (IC50 = 300 nM against GW1516-induced PPARβ/δ reporter activity; IC50 = 155 nM vs >10 µM for PPARα and PPARγ by GW1516 displacement binding assays). GSK0660 effectively antagonizes PPARβ/δ agonist GW501516 (GW1516)-induced target genes expression in multiple cell types, including HuH7, rat L6 myotubes, and mouse BMDMs (1-10 nM GW1516, 100-1000 nM GSK0660).
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
No data available
flash_point_c
No data available