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About This Item
Empirical Formula (Hill Notation):
C22H19FN4O2
CAS Number:
Molecular Weight:
390.41
MDL number:
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Application
Chidamide may be used as an enhancer of zeste homolog 2 (EZH2) inhibitor and study the antileukemia effects in vivo in leukemia-bearing nude mouse models
Biochem/physiol Actions
Chidamide (CS055, HBI-8000, Tucidinostat) is an orally available benzamide that inhibits against class I histone deaceylases HDAC1/2/3/8 (IC50 of 95/160/67/733 nM), class II2b HDAC10 (IC50 = 78 nM), and class IV HDAC11 (IC50 = 432 nM), but not class IIa HDAC4/5/7/9 or IIb HDAC10 (IC50 >30 μM). Chidamide effectively upregulates cellular acetylation levels of histone H3 and H4 (3 μM for 24 h in SKM-1 and HEL cultures) and exhibits anti-cancer efficacy both in cultures and in vivo.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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