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Merck
CN

SML4258

Spexin 1 trifluoroacetate

new

≥95% (HPLC)

Synonym(s):

H-Asn-Trp-Thr-Pro-Gln-Ala-Met-Leu-Tyr-Leu-Lys-Gly-Ala-Gln-NH₂ trifluoroacetate, L-Asparaginyl-L-tryptophyl-L-threonyl-L-prolyl-L-glutaminyl-L-alanyl-L-methionyl-L-leucyl-L-tyrosyl-L-leucyl-L-lysylglycyl-L-alanyl-L-glutamamide trifluoroacetate, Spexin trifluoroacetate, SPX trifluoroacetate, SPX1 trifluoroacetate, Neuropeptide Q trifluoroacetate, NPQ trifluoroacetate, NPQ 53-70 trifluoroacetate, NWTPQAMLYLKGAQ-NH2 trifluoroacetate

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About This Item

Empirical Formula (Hill Notation):
C74H114N20O19S · xC2HF3O2
CAS Number:
1370290-58-6
Molecular Weight:
1619.88 (free base basis)
UNSPSC Code:
12352200

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Quality Level

100

Assay

≥95% (HPLC)

form

(Powder or Lyophilized powder or film)

storage condition

desiccated

color

white to off-white

storage temp.

-10 to -25°C

General description

Endogenous galanin receptor GAL2/3 agonist with anti-obesity efficacy in cultures and in vivo.
Spexin 1 (SPX) is a 14-aa amidated peptide that acts as an endogenous galanin receptor GAL2/3 agonist (EC50 = 161 nM/GAL2, 626 nM/GAL3, >10 µM/GAL1 by reporter assays using respective HEK293 transfectants) that inhibits facilitated fatty acid (FA) uptake in diet-induced obesity (DIO) mouse adipocytes cultures (0.1-1 ng/mL) and induces rat stomach muscle contraction ex vivo (EC50 = 750 nM). SPX reduces caloric intake in rats (∼32%; 35 µg/kg/day s.c.) with corresponding weight loss and significantly reduces the RER at night as well as increases locomotion in mice in vivo (25 µg/kg/day i.p.). Note: peptide sequence is conserved in human, murine, rat and many other mammalian species.

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José L Walewski et al.
Obesity (Silver Spring, Md.), 22(7), 1643-1652 (2014-02-20)
Microarray studies identified Ch12:orf39 (Spexin) as the most down-regulated gene in obese human fat. Therefore, we examined its role in obesity pathogenesis. Spexin effects on food intake, meal patterns, body weight, respiratory exchange ratio (RER), and locomotor activity were monitored
Olivier Mirabeau et al.
Genome research, 17(3), 320-327 (2007-02-08)
Peptide hormones are small, processed, and secreted peptides that signal via membrane receptors and play critical roles in normal and pathological physiology. The search for novel peptide hormones has been hampered by their small size, low or restricted expression, and
Dong-Kyu Kim et al.
Endocrinology, 155(5), 1864-1873 (2014-02-13)
The novel neuropeptide spexin (SPX) was discovered using bioinformatics. The function of this peptide is currently under investigation. Here, we identified SPX along with a second SPX gene (SPX2) in vertebrate genomes. Syntenic analysis and relocating SPXs and their neighbor

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