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About This Item
Empirical Formula (Hill Notation):
C74H114N20O19S · xC2HF3O2
CAS Number:
Molecular Weight:
1619.88 (free base basis)
Assay:
≥95% (HPLC)
Form:
(Powder or Lyophilized powder or film)
Quality level:
Storage condition:
desiccated
Quality Level
assay
≥95% (HPLC)
form
(Powder or Lyophilized powder or film)
storage condition
desiccated
color
white to off-white
storage temp.
-10 to -25°C
General description
Spexin is a 4-amino acidpeptide, produced by neurons in the hypothalamus.
Application
Spexin for its potential roles in regulating appetite and metabolism,influencing reproductive hormones, in metabolic and endocrine research.
Biochem/physiol Actions
Spexin 1 (SPX) is a 14-aa amidated peptide that acts as an endogenousgalanin receptor GAL2/3 agonist (EC50 = 161 nM/GAL2, 626 nM/GAL3, >10µM/GAL1 by reporter assays using respective HEK293 transfectants) that inhibits facilitated fatty acid (FA) uptake in diet-induced obesity (DIO) mouse adipocytes cultures (0.1-1 ng/mL) and induces rat stomach muscle contraction ex vivo (EC50 = 750 nM). SPX reduces caloric intake in rats (∼32%; 35 µg/kg/day s.c.) with corresponding weight loss and significantly reduces the RER at night as well as increases locomotion in mice in vivo (25 µg/kg/day i.p.). Note: peptide sequence is conserved in human, murine, rat and many other mammalian species.
Disclaimer
Hygroscopic Store with desiccant
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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José L Walewski et al.
Obesity (Silver Spring, Md.), 22(7), 1643-1652 (2014-02-20)
Microarray studies identified Ch12:orf39 (Spexin) as the most down-regulated gene in obese human fat. Therefore, we examined its role in obesity pathogenesis. Spexin effects on food intake, meal patterns, body weight, respiratory exchange ratio (RER), and locomotor activity were monitored
Olivier Mirabeau et al.
Genome research, 17(3), 320-327 (2007-02-08)
Peptide hormones are small, processed, and secreted peptides that signal via membrane receptors and play critical roles in normal and pathological physiology. The search for novel peptide hormones has been hampered by their small size, low or restricted expression, and
Dong-Kyu Kim et al.
Endocrinology, 155(5), 1864-1873 (2014-02-13)
The novel neuropeptide spexin (SPX) was discovered using bioinformatics. The function of this peptide is currently under investigation. Here, we identified SPX along with a second SPX gene (SPX2) in vertebrate genomes. Syntenic analysis and relocating SPXs and their neighbor
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