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Merck
CN

SML4326

IKE

≥97% (HPLC)

Synonym(s):

2-[[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]-4(3H)-quinazolinone, Imidazole ketone erastin

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About This Item

Empirical Formula (Hill Notation):
C35H35ClN6O5
CAS Number:
Molecular Weight:
655.14
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
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assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

Biochem/physiol Actions

IKE (Imidazole ketone erastin) is a highly potent and metabolically stable inhibitor of system xc– and inducer of ferroptosis. It appears that IKE inhibits cystine uptake leading to glutathione depletion. IKE inhibits tumor growth in mouse model of lymphoma.

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Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

Regulatory Information

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