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Merck
CN

SML4343

ML228

≥98% (HPLC)

Synonym(s):

CID 46742353, CID-46742353, CID46742353, ML 228, ML-228, N-([1,1′-Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine

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About This Item

Empirical Formula (Hill Notation):
C27H21N5
CAS Number:
1357171-62-0
Molecular Weight:
415.49
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

ML228 is a hypoxia inducible factor (HIF) pathway activator (EC50 = 1.23 μM by U2OS-based HRE-luciferase reporter assay) that induces HIF-1α nuclear translocation (EC50 = 1.23 μM) and downstream targets transcription (EC50 = 1.63 μM by VEGF RT-PCR).

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