SRE0022
β-Glucuronidase from abalone
Chromatographically purified, lyophilized powder, β-glucuronidase ≥20,000,000 units/g protein
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About This Item
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-606-8
MDL number:
Biological source:
abalone
biological source
abalone
form
lyophilized powder
β-glucuronidase activity
≥20,000,000 units/g protein
secondary activity
≤4,000,000 units/g protein sulfatase
composition
protein, 10-40%
storage temp.
−20°C
Application
β-Glucuronidase from abalone has been used in enzyme treatment to know the effect of osmotic shock, enzymatic incubation, pulsed electric field, and high shear homogenization on the release of water-soluble proteins and carbohydrates from the green alga Ulva lactuca.
Technical Article Comparing Performance of Different Enzymes
Learn more
about recent application data generated by Sigma R&D to optimize hydrolysis for different drug classes using enzymes from different sources and the use of a chromatographicaly purified enzyme to reduce the effect of esterase activity resulting in conversion of 6-MAM to Morphine.
Learn more
about recent application data generated by Sigma R&D to optimize hydrolysis for different drug classes using enzymes from different sources and the use of a chromatographicaly purified enzyme to reduce the effect of esterase activity resulting in conversion of 6-MAM to Morphine.
Biochem/physiol Actions
β-Glucuronidase (GUSB) is a lysosomal enzyme. It degrades glucuronate-containing glycosaminoglycan. β-glucuronidase, obtained from abalone has the ability to hydrolyze samples, that has high analyte concentrations. Deficiency of β-glucuronidase results in mucopolysaccharidosis type VII (MPSVII), which leads to lysosomal storage in the brain.
Physical form
Supplied as a lyophilized powder containing Trizma® and L-arginine
Other Notes
One Sigma or modified Fishman unit will liberate 1.0 μg of phenolphthalein from phenolphthalein glucuronide per hr at 37 °C at pH 3.8 (30 min assay).
Legal Information
Trizma is a registered trademark of Merck KGaA, Darmstadt, Germany
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Danger
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
wgk
WGK 1
Regulatory Information
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Articles
β-glucuronidase (GUS) enzymes are utilized to hydrolyze glucuronide (gluc) drug metabolites to the parent drug, facilitating analysis by LC-MS/MS.
Biorefinery of the macroalgae Ulva lactuca: extraction of proteins and carbohydrates by mild disintegration
Postma P R, et al.
Journal of Applied Phycology, 1-13 (2018)
Evaluation of abalone beta-glucuronidase substitution in current urine hydrolysis procedures
Malik W B, et al.
Journal of Analytical Toxicology, 38(3), 171-176 (2014)
P R Postma et al.
Journal of applied phycology, 30(2), 1281-1293 (2018-05-15)
The effect of osmotic shock, enzymatic incubation, pulsed electric field, and high shear homogenization on the release of water-soluble proteins and carbohydrates from the green alga Ulva lactuca was investigated in this screening study. For osmotic shock, both temperature and
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SRE0022-2MU | 04061832844909 |
| SRE0022-1MU | 04061826694442 |
| SRE0022-500KU | 04061832844916 |