SRP0363
Cot active mouse
recombinant, expressed in baculovirus infected Sf9 cells, ≥50% (SDS-PAGE)
Synonym(s):
Cot, Map3k8, Tpl2, mitogen-activated protein kinase kinase kinase 8
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
biological source
mouse
recombinant
expressed in baculovirus infected Sf9 cells
Assay
≥50% (SDS-PAGE)
form
aqueous solution
mol wt
70 kDa
packaging
pkg of 10 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
mouse ... MAP3K8(26410)
General description
Mouse Cot kinase (MAP3K8) (GenBank Accession No. NM_007746), amino acids 30-397 with N-terminal His-GST-tag, expressed in a Baculovirus infected Sf9 cell expression system.
Physical form
Formulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.4 mM KCl, 5 mM glutathione, 134 mM imidazole, 3 mM DTT and 20% glycerol.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Irene Soria-Castro et al.
The Journal of biological chemistry, 285(44), 33805-33815 (2010-08-26)
Cot/tpl2 (also known as MAP3K8) has emerged as a new and potentially interesting therapeutic anti-inflammatory target. Here, we report the first study of Cot/tpl2 involvement in acute peripheral inflammation in vivo. Six hours after an intraplantar injection of zymosan, Cot/tpl2(-/-)
Joseph H Jeong et al.
PloS one, 6(1), e16205-e16205 (2011-01-27)
Despite its initial positive response to hormone ablation therapy, prostate cancers invariably recur in more aggressive, treatment resistant forms. The lack of our understanding of underlying genetic alterations for the transition from androgen-dependent (AD) to ADI prostate cancer growth hampers
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