SRP0370
MUSK active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)
Synonym(s):
muscle, skeletal, receptor tyrosine kinase
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About This Item
Assay:
≥70% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf9 cells
Concentration:
0.11 mg/mL
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥70% (SDS-PAGE)
form
aqueous solution
mol wt
38.5 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
0.11 mg/mL
technique(s)
activity assay: suitable, inhibition assay: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MUSK(4593)
General description
Human MUSK (GenBank Accession No. NM_005592), amino acids 530-end with N-terminal His-tag, MW = 38.5 kDa, expressed in Baculovirus infected Sf9 cell expression system.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Amelia Evoli et al.
Annals of the New York Academy of Sciences, 1132, 76-83 (2008-06-24)
Myasthenia gravis (MG) with antibodies against the muscle-specific tyrosine kinase (MuSK abs) is often a severe disease requiring aggressive treatment. Various immunosuppressive (IS) regimens have been employed; the efficacy of plasma exchange is unanimously recognized, while the indication for thymectomy
H Zhou et al.
The Journal of cell biology, 146(5), 1133-1146 (1999-09-09)
Agrin released from motor nerve terminals activates a muscle-specific receptor tyrosine kinase (MuSK) in muscle cells to trigger formation of the skeletal neuromuscular junction. A key step in synaptogenesis is the aggregation of acetylcholine receptors (AChRs) in the postsynaptic membrane
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SRP0370-10UG | 04061837196348 |
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