SRP0375
LOXL2 human
recombinant, expressed in FreeStyle™ 293-F cells, ≥86% (SDS-PAGE)
Synonym(s):
LOR2, WS9-14, lysyl oxidase-like 2
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
biological source
human
recombinant
expressed in FreeStyle™ 293-F cells
Assay
≥86% (SDS-PAGE)
form
aqueous solution
mol wt
85 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
0.23 mg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... LOXL2(4017)
General description
Human LOXL2 (GenBank Accession No. NM_002318), amino acids 26 – 774 (end) with C-terminal His tag, MW = 85 kDa, expressed in FreeStyle 293-F cells.
Lysyl oxidase like 2 (LOXL2) is part of the LOX family of proteins. It is widely expressed. The gene encoding this protein is localized on human chromosome 8p21.3. It has a conserved carboxy-terminal region with a catalytic function and a divergent amino-terminal region.
Biochem/physiol Actions
Lysyl oxidase like 2 (LOXL2) is an amino oxidase. LOXL2 is involved in various cellular events such as gene transcription, cell migration, adhesion and differentiation. The protein has a role in connecting collagen and/or elastin in the extracellular matrix. It deaminates trimethylated lysine 4 in histone H3, causing transcriptional repression. LOXL2 suppresses some TFIID (transcription factor IID)-associated genes by oxidising methylated TAF10 (TATA-box binding protein associated factor 10). The LOXL2 gene is upregulated in various cancers, such as gastric cancer, breast cancer and squamous cell carcinomas. The gene is associated with cancer cell invasion and lymph node metastasis.
Physical form
Formulated in 8 mM PBS, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, and 20% glycerol.
Legal Information
FreeStyle is a trademark of Invitrogen Corp.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Verena Aumiller et al.
Scientific reports, 7(1), 149-149 (2017-03-10)
Extracellular matrix (ECM) composition and stiffness are major driving forces for the development and persistence of fibrotic diseases. Lysyl oxidase (LOX) and LOX-like (LOXL) proteins play crucial roles in ECM remodeling due to their collagen crosslinking and intracellular functions. Here
Olivier G de Jong et al.
Journal of cellular and molecular medicine, 20(2), 342-350 (2015-11-28)
Exosomes are important mediators of intercellular communication. Additionally, they contain a variety of components capable of interacting with the extracellular matrix (ECM), including integrins, matrix metalloproteinases and members of the immunoglobin superfamily. Despite these observations, research on exosome-ECM interactions is
Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression
Alberto Martin
The Embo Journal, 34(5), 1090-1109 (2015)
Nicolás Herranz et al.
The FEBS journal, 283(23), 4263-4273 (2016-11-01)
Methylation of histone H3 lysine 4 is linked to active transcription and can be removed by LSD1 or the JmjC domain-containing proteins by amino-oxidation or hydroxylation, respectively. Here we describe that its deamination can be catalyzed by lysyl oxidase-like 2
The LOXL2 Gene Encodes a New Lysyl Oxidase-like Protein and Is Expressed at High Levels in Reproductive Tissues*
Claude Jourdan-Le Saux
The Journal of Biological Chemistry (1999)
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