SRP0389
PRMT6 active human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Synonym(s):
HRMT1L6, Histone-arginine N-methyltransferase 6, protein arginine N-methyltransferase 6
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
biological source
human
recombinant
expressed in E. coli
Assay
≥70% (SDS-PAGE)
form
aqueous solution
mol wt
43 kDa
packaging
pkg of 20 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PRMT6(55170)
General description
Protein arginine methyltransferase 6 (PRMT6) is a 41.9kDa protein with 375 amino acids. It is encoded by the gene mapped to human chromosome 1. It belongs to type I enzyme, which is a subclass of PRMT family. PRMT6 is localized exclusively in nucleus.
Human PRMT6 (GenBank Accession No. NM_018137), amino-acids 2-375 (end), with N-terminal His-tag, MW=43kDa, expressed in Escherichia coli.
Human PRMT6 (GenBank Accession No. NM_018137), amino-acids 2-375 (end), with N-terminal His-tag, MW=43kDa, expressed in Escherichia coli.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Biochem/physiol Actions
Protein arginine methyltransferase 6 (PRMT6) catalyze the formation of asymmetric ω-NG,NG -dimethylarginine residues. In addition, PRMT6 show automethylation activity, which is unique among the members of PRMT family. PRMT6 mediates cigarette smoke extract (CSE)-triggered apoptosis and inflammation via di-methylation H3 arginine 2 (H3R2me2a) in human umbilical vein endothelial cells (HUVECs). PRMT6 plays a crucial role in various physiological processes such as transcriptional regulation, DNA repair and human immunodeficiency virus pathogenesis. Upregulated expression of the enzyme might be favorable for tumor growth and progression. Overexpression of PRMT6 has been observed in various type of malignancies including breast, cervix, bladder, prostate and lung cancer.
Physical form
Formulated in 200 mM imidazole, 20% glycerol, and 3 mM DTT.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes.
Stein C
Nucleic Acids Research, 40(19), 9522-9533 (2012)
Identification and characterization of new molecular partners for the protein arginine methyltransferase 6 (PRMT6).
Lo Sardo A
PLoS ONE, 8(1), e53750-e53750 (2013)
PRMT6 mediates CSE induced inflammation and apoptosis.
Kang N
International Immunopharmacology, 24(1), 95-101 (2015)
Ernesto Guccione et al.
Nature, 449(7164), 933-937 (2007-09-28)
Eukaryotic genomes are organized into active (euchromatic) and inactive (heterochromatic) chromatin domains. Post-translational modifications of histones (or 'marks') are key in defining these functional states, particularly in promoter regions. Mutual regulatory interactions between these marks--and the enzymes that catalyse them--contribute
The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity.
Frankel A
The Journal of Biological Chemistry, 277(5), 3537-3543 (2002)
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