Assay
≥95% (HPLC)
form
aqueous solution
mol wt
2728.2 kDa
packaging
pkg of 5 mL
shipped in
dry ice
storage temp.
−70°C
General description
BET (bromodomains and extra-terminal) domain is a highly conserved motif composed of 110 amino acids. It is composed of four anti-parallel α-helices, and contains a bromodomain in the amino-terminal region and an extraterminal (ET) protein-protein interaction domain in the carboxy-terminal region. The two conserved loops are linked with a hydrophobic cleft. This domain is present in BRD (bromodomain-containing) proteins, such as BRD2, BRD3 and BRD4, and these proteins are thus known as BET family proteins. Humans are thought to contain 56 bromodomains present in 42 proteins.
Biochem/physiol Actions
BRD (bromodomain) proteins are known as chromatin “readers”, as they recruit chromatin-regulating enzymes which are responsible for histone modification. These proteins eventually act on promoters and control gene expression.
Storage Class Code
12 - Non Combustible Liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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