SRP0570
5′-NUCLEOTIDASE/CD73, His-Tag
recombinant, expressed in HEK 293 cells
Synonym(s):
5′- nucleotidase, Ecto-5′-nucleotidase
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.26
recombinant
expressed in HEK 293 cells
form
frozen liquid
mol wt
58.6 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... NT5E(4907)
General description
5′-Nucleotidase/CD73 is glycosyl-phosphatidyl inositol (GPI)- anchored cell surface protein. Itis present in various tissues and cells including endothelial cells, epithelialcells, and subsets of B and T cells.
Application
5′-Nucleotidase/CD73 has been used as a standard in recombinanthuman CD73 assay.
Biochem/physiol Actions
5′-Nucleotidase/CD73 actsas a rate-limiting enzyme to produce adenosine. It helps in upholding tissuehomeostasis by converting the adenosine triphosphate (ATP)-triggered immuneactivation to adenosine-mediated immunosuppression.CD73 is a novel immunoinhibitory protein that participates in tumor growthand metastasis. CD73 in combination with conventional therapy and/or otherimmune checkpoint inhibitors has been reported to show therapeutic effectsagainst cancer.
Physical form
Aqueous solution
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Amanda de Fraga Dias et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 162, 105823-105823 (2021-03-31)
Glioblastoma (GBM) is the most frequent and aggressive brain tumor in adults and the current treatments only have a modest effect on patient survival. Recent studies show that bozepinib (BZP), a purine derivative, has potential applications in cancer treatment. The
Targeting CD73 to augment cancer immunotherapy
Meejeon Roh, et al.
Current Opinion in Psychiatry, 53, 66-76 (2020)
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