SRP2022
PC4, wild type human
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Synonym(s):
MGC102747, P15, PC4, p14
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About This Item
NACRES:
NA.26
UNSPSC Code:
12352202
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥80% (SDS-PAGE)
Form:
frozen liquid
Mol wt:
~14.4 kDa
biological source
human
recombinant
expressed in E. coli
assay
≥80% (SDS-PAGE)
form
frozen liquid
mol wt
~14.4 kDa
packaging
pkg of 10 μg
concentration
1000 μg/mL
color
clear colorless
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... SUB1(10923)
General description
PC4 or SUB1 homolog is a single-stranded DNA-binding protein. It is expressed in the nucleus. The gene encoding this protein is localized on human chromosome 5p13.3.
Biochem/physiol Actions
It plays an important role in DNA damage repair, replication and cellular transformation. It also has a role in the organization of the chromatin. The protein has been shown to be overexpressed in astrocytoma.
The human PC4 is a non-TAF transcription coactivator that mediates activator-dependent transcription by RNA polymerase II in vitro through most tested activators. The function of PC4 is apparently through interactions with transcriptional activators and the basal transcription machinery. It is negatively regulated by casein kinase II phosphorylation both in vitro and in vivo. PC4 strongly binds single stranded DNA and regulates HSSB (RPA)-dependent SV40 DNA replication. Recent studies indicated that PC4 can be acetylated by several histone acetyltransferases.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
TAFs Enhance the Recruitment of RNA Polymerase II by
Transcriptional Activators
Transcriptional Activators
Shwu-Yuan Wu and Cheng-Ming Chiang
The Journal of Biological Chemistry (2001)
Spaceflight alters the gene expression profile of cervical cancer cells
Zhi-Jie Zhang
Chinese Journal of Cancer, 30(12), 842-852 (2011)
Activator-dependent transcription by mammalian RNA polymerase II: in vitro reconstitution with general transcription factors and cofactors.
H Ge et al.
Methods in enzymology, 274, 57-71 (1996-01-01)
Human positive coactivator 4 (PC4) is involved in the progression and prognosis of astrocytoma.
Chen L
Journal of the Neurological Sciences, 346(1-2), 293-298 (2014)
PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites.
Mortusewicz O
Oncogene, 35(6), 761-770 (2016)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SRP2022-10UG | 04061832782980 |
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