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SRP2144

Sigma-Aldrich

SRC1, receptor interaction domain (627-786), GST tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Synonym(s):

F-SRC-1, KAT13A, MGC129719, MGC129720, RIP160, SRC1, bHLHe42, bHLHe74

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10 μG
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Estimated to ship on2025年10月27日Details

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10 μG
¥2,877.56

About This Item

UNSPSC Code:
12352200
NACRES:
NA.77

¥2,877.56

Estimated to ship on2025年10月27日Details

New, lower price on this item!
Request a Bulk Order
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biological source

human

recombinant

expressed in E. coli

Assay

≥80% (SDS-PAGE)

form

frozen liquid

mol wt

~44 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

500 μg/mL

color

clear colorless

NCBI accession no.

NM_003743

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SRC1, receptor interaction domain (627-786), GST tagged human recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

SRP2144

SRC1, receptor interaction domain (627-786), GST tagged human

SRC1, His tagged, TEV site, human recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

SRP2068

SRC1, His tagged, TEV site, human

SRC1, FLAG tagged, TEV site human recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

SRP2075

SRC1, FLAG tagged, TEV site human

SRC1, untagged human recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

SRP2069

SRC1, untagged human

biological source

human

biological source

human

biological source

human

biological source

human

assay

≥80% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

Gene Information

human ... NCOA1(8648)

Gene Information

human ... NCOA1(8648)

Gene Information

human ... NCOA1(8648)

Gene Information

human ... NCOA1(8648)

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

form

frozen liquid

form

frozen liquid

form

frozen liquid

form

frozen liquid

concentration

500 μg/mL

concentration

400 μg/mL

concentration

1000 μg/mL

concentration

400 μg/mL

Biochem/physiol Actions

Steroid receptor coactivator 1 (SRC1) is a transcriptional coactivator that mediates the activating functions of many of the nuclear hormone receptors. It is also known as NCoA1 and is a member of the SRC/p160 coactivator family. SRC1 is a 160 kDa protein that contains several LXXLL motifs, which are involved in nuclear receptor interaction. The region 627-786 contains 3 LXXLL motifs that are involved in interaction with nuclear hormone receptors and has been previously used in assays detecting ligand-dependent receptor-cofactor interactions.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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    Lot/Batch Number
    063097053

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    Jianming Xu et al.
    Molecular endocrinology (Baltimore, Md.), 17(9), 1681-1692 (2003-06-14)
    The p160 steroid receptor coactivator (SRC) gene family contains three homologous members, which serve as transcriptional coactivators for nuclear receptors and certain other transcription factors. These coactivators interact with ligand-bound nuclear receptors to recruit histone acetyltransferases and methyltransferases to specific
    S A Oñate et al.
    Science (New York, N.Y.), 270(5240), 1354-1357 (1995-11-24)
    A yeast two-hybrid system was used to identify a protein that interacts with and enhances the human progesterone receptor (hPR) transcriptional activity without altering the basal activity of the promoter. Because the protein stimulated transactivation of all the steroid receptors
    D M Heery et al.
    Nature, 387(6634), 733-736 (1997-06-12)
    The binding of lipophilic hormones, retinoids and vitamins to members of the nuclear-receptor superfamily modifies the DNA-binding and transcriptional properties of these receptors, resulting in the activation or repression of target genes. Ligand binding induces conformational changes in nuclear receptors

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