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SRP3059

Interferon-λ human

Name: Interferon-λ human
Brand: SIGMA

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Synonym(s):

IFN-λ human, IL-29

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About This Item

NACRES:

NA.32

UNSPSC Code:

12352202

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Properties

biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

form

lyophilized

potency

0.2-0.5 ng/mL ED₅₀

mol wt

19.8 kDa

packaging

pkg of 20 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white to off-white

UniProt accession no.

Q8IU54

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL29(282618)

Description

General description

IFN-λ-1,-2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family of interferons. All three IFN-λs use a distinct receptor system composed of an IFN-λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons. Recombinant human IFN-L1 is a 19.8kDa protein containing 178 amino acid residues.

Biochem/physiol Actions

Interleukin-29 (IL-29) enhances the production of interleukins from monocytes. It has been observed that it stimulates antiviral responses to herpes simplex virus 1 in vitro. Serums from patients with rheumatoid arthritis have high levels of IL29.

Physical form

Lyophilized from 1x PBS.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Other Notes

PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)