SRP3193
Cardiotrophin-1 from mouse
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonym(s):
CT-1
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
biological source
mouse
recombinant
expressed in E. coli
Assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
potency
≤1.0 ng/mL ED50
mol wt
21.3 kDa
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
off-white to yellow
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... CTF1(13019)
General description
Cardiotrophin-1 is from interleukin (IL)-6 family of cytokines. It is mainly present in adipose tissues, osteoclasts and cardiomyocytes. Cardiotrophin-1 works through gp130 (glycoprotein) and the LIFR (LIF receptor).
Biochem/physiol Actions
In adipocytes, cardiotrophin-1 helps in activating signaling pathways associated with metabolism. It controls energy homeostasis, and glucose and lipid metabolism. High levels of cardiotrophin-1 are reported in obesity and metabolic syndrome. Absence of cardiotrophin-1 in mice causes mature-onset obesity, insulin resistance and hypercholesterolemia. In osteoclasts, it enhances osteoblast activity as well as mineralization. It also participates in cardiomyocyte survival, hypertrophy, cardiac fibroblast proliferation and collagen type I synthesis. Cardiotrophin-1 is associated with arterial fibrosis and stiffness.
Sequence
SQREGSLEDH QTDSSISFLP HLEAKIRQTH NLARLLTKYA EQLLEEYVQQ QGEPFGLPGF SPPRLPLAGL SGPAPSHAGL PVSERLRQDA AALSVLPALL DAVRRRQAEL NPRAPRLLRS LEDAARQVRA LGAAVETVLA ALGAAARGPG PEPVTVATLF TANSTAGIFS AKVLGFHVCG LYGEWVSRTE GDLGQLVPGG VA
Physical form
Lyophilized from 0.5mg/ml in 5mM Tris, pH 8.0.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1- 1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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