FGF-10 human

FGF10 (fibroblast growth factor 10) is a member of the FGF protein family, and is a mitogen of epithelial origin and has paracrine activity. It is produced by mesenchymal lineage cells, and acts as a ligand for FGFR, most notably FGFR2b, which is expressed by epithelial cells.
Recombinant human FGF-10 is a 19.3 kDa protein consisting of 170 amino acid residues.

FGF10 (fibroblast growth factor 10) is involved in cell growth, morphogenesis and embryogenesis. It pays an essential role in initiating the formation of limb bud, lung morphogenesis and brain formation during embryogenesis. It acts as a mitogen where it facilitates the regeneration of epithelia post-bladder urothelial injury. Thus, it might have future applications during bladder transplantation. Studies in Japanese population show that polymosphisms- rs339501, rs12517396, and rs10462070 are linked with severe myopia, and might act as susceptibility factors for the same. In lung cancer cells, FGFR4 reduces the stem cell/self-renewal property of cancer cells, and makes them more susceptible to chemotherapy.

Lyophilized from 5 mM Sodium Phosphate, pH 7.4 + 80 mM NaCl.

Centrifuge the vial prior to opening. Reconstitute in 5 mM Sodium Phosphate, pH 7.4 to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.