SRP3292
R-SPONDIN-1 human
recombinant, expressed in CHO cells, ≥95% (SDS-PAGE)
Synonym(s):
Rspo1
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
biological source
human
recombinant
expressed in CHO cells
assay
≥95% (SDS-PAGE)
form
lyophilized
potency
≤50 ng/mL ED50
mol wt
monomer (26.8 kDa (243 amino acids))
packaging
pkg of 20 μg
impurities
<0.1 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... RSPO1(284654)
General description
R-Spondin-1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the (Rspo) family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. Rspo-1 is expressed in certain areas of the developing central nervous system, as well as in adrenal glands, ovary, testis, thyroid, and trachea. Recombinant human R-Spondin-1 is a 26.7kDa protein consisting of 243 amino acid residues. Due to glycosylation, R-Spondin-1 migrates at an apparent molecular weight of approximately 40.0kDa by SDS PAGE analysis under reducing conditions.
Biochem/physiol Actions
Rspo (R-Spondin) can interact with the Frizzled/LRP6 (LDL receptor related protein 6) receptor complex in a manner that stimulates the Wnt/beta-catenin signaling pathway. Disruption of Rspo-1 gene causes recessive syndrome with XX sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Rspo-1 is also associated with radioresistance of tumor cells.
Physical form
Lyophilized from a 0.2 μm filtered solution containingPhosphate Buffered Saline (PBS)
Preparation Note
Sterile water at 0.1 mg/mLCentrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C, and avoid repeat freeze thaws.
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Articles
Organoid culture products to generate tissue and stem cell derived 3D brain, intestinal, gut, lung and cancer tumor organoid models.
可生成组织和干细胞来源3D脑、胃肠道、肺和癌症肿瘤类器官模型的类器官培养产品。
R-spondin1 is essential in sex determination, skin differentiation and malignancy.
Parma P, et al.
Nature Genetics, 38, 1304-1309 (2006)
R-Spondin proteins: a novel link to beta-catenin activation.
Kim KA, et al.
Cell Cycle, 5, 23-26 (2006)
Xuefeng Gu et al.
Oncotarget, 6(12), 9756-9765 (2015-04-14)
Although radiation therapy is the most effective postoperative adjuvant treatment, it does not substantially improve the long-term outcomes of glioma patients because of the characteristic radioresistance of glioma. We found that R-Spondin1 (Rspo1) expression was elevated in high-grade gliomas and
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SRP3292-20UG | 04061837225482 |