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Merck
CN

SRP3307

Sigma-Aldrich

FGF-8 human

Animal-component free, recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)

Synonym(s):

AIGF, FGF-8b, HBGF

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About This Item

UNSPSC Code:
12352202
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biological source

human

recombinant

expressed in E. coli

Assay

≥97% (HPLC)
≥97% (SDS-PAGE)

form

lyophilized

potency

2.0-4.0 ng/mL

mol wt

22.5 kDa

packaging

pkg of 25 μg

impurities

endotoxin, tested

color

white to off-white

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FGF8(2253)

General description

FGF-8 (FGF-8b) is a heparin binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF8A, FGF-8B, FGF-8E and FGF-8F. The human and murine FGF8 A and B are identical unlike human and mouse FGF8 E and F are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. Recombinant human FGF-8 (FGF-8b) is a 22.5 kDa protein consisting of 194 amino acid residues.

Biochem/physiol Actions

FGF-8 (FGF-8b) is a heparin binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. . Recombinant human FGF-8 (FGF-8b) is a 22.5 kDa protein consisting of 194 amino acid residues.

Physical form

Lyophilized from 10 mM Sodium Phosphate pH, 8.0 + 75 mM NaCl.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品
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Fibroblast growth factors.
Ornitz, D.M. and Itoh, N.
Genome Biology, 2, 3005-3005 (2001)

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