SRP4028
Eotaxin human
recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)
Synonym(s):
CCL11, Eosinophil chemotactic protein chemokine (C-C motif) ligand 11, MGC22554, SCYA11, Small inducible cytokine A11
biological source
human
recombinant
expressed in E. coli
assay
≥97% (HPLC), ≥97% (SDS-PAGE)
form
lyophilized
potency
10 ng/mL
mol wt
~8.3 kDa
packaging
pkg of 20 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CCL11(6356)
General description
Eotaxin is a chemokine and belongs to the Th2 (T helper 2) cytokine family. It is expressed in many organs, such as heart, central nervous system and the cerebrospinal fluid. The associated gene (CCL11 (C-C motif chemokine ligand 11)) is mapped to human chromosome 17q12.
Biochem/physiol Actions
Eotaxin participates in immunoregulatory and inflammatory responses. It works as a chemoattractant for many immune cells, including eosinophils, basophils, myeloid cells and T-helper 2 lymphocytes. The eotaxin gene is associated with atopic dermatitis, allergic rhinitis, sinusitis, asthma, ulcerative colitis, gastrointestinal disorders and parasitic infections. It is also involved with the pathogenesis of ovarian and gastric cancer. Eotaxin plays a significant role in the aging processes.
Physical form
Sterile filtered and Lyophilized without additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstituted in water to a concentration of 0.1-1 μg/μL. It is recommended that further dilutions be made into buffer containing carrier protein or medium containing serum.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Rossana C N Melo et al.
PloS one, 8(3), e59578-e59578 (2013-04-05)
Lipid bodies (LBs), also known as lipid droplets, are complex organelles of all eukaryotic cells linked to a variety of biological functions as well as to the development of human diseases. In cells from the immune system, such as eosinophils
Kimberly D Dyer et al.
PloS one, 10(3), e0118887-e0118887 (2015-03-17)
HMGB1 is an alarmin that can stimulate the innate immune system alone or in a complex with other inflammatory mediators. Given the recent interest in HMGB1 with respect to the pathogenesis of eosinophil-associated disorders, including asthmatic inflammation and chronic rhinosinusitis
Mustafa Ahmadzai et al.
Frontiers in immunology, 6, 525-525 (2015-11-06)
Eosinophil migration to the lung is primarily regulated by the eosinophil-selective family of eotaxin chemokines, which mobilize intracellular calcium (Ca(2+)) and orchestrate myriad changes in cell structure and function. Eosinophil function is also known to be flow-dependent, although the molecular
Is Eotaxin-1 a serum and urinary biomarker for prostate cancer detection and recurrence?
Heidegger I, et al.
Prostate, 75, 1904-1904 (2015)
Serum eotaxin-1 is increased in extremely-low-birth-weight infants with bronchopulmonary dysplasia or death.
Kandasamy J, et al.
Pediatric Research, 78, 498-498 (2015)
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