SRP4029
Eotaxin from mouse
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym(s):
CCL11, Eosinophil chemotactic protein chemokine (C-C motif) ligand 11, SCYA11, Small inducible cytokine A11
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About This Item
UNSPSC Code:
12352202
MDL number:
biological source
mouse
recombinant
expressed in E. coli
assay
≥98% (HPLC), ≥98% (SDS-PAGE)
form
lyophilized
mol wt
~8.4 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Ccl11(20292)
General description
Eotaxin is a member of the CC chemokine family, and belongs to the MCP/eotaxin subfamily. It has a wide range of tissue expression, such as thymus, heart, lungs, lymph nodes, kidney, and intestines. It is also expressed by epithelial cells of lung, pleural mesothelial cells, epithelial cells of bronchial airway, and smooth muscle cells (SMCs).
Biochem/physiol Actions
Eotaxin is a chemoattractant for eosinophils, and is involved inflammatory diseases, such as asthma. It is induced by glucocorticoids and cytokines. Along with interleukin-5 (IL-5) it results in airway hyperresponsiveness (AHR), and hence, lung inflammatory disorders. In humans, it leads to respiratory syncytial virus (RSV) vaccine-enhanced disease, and the eosinophils are also responsible for the elimination of virus. It might also be involved in the pathophysiology of inflammatory bowel diseases which involve eosinophils. It can lead to the production of reactive oxygen species, thus, resulting in damaged tissue. It is overexpressed in multiple diseases such as allergic rhinitis, nasal polyposis, endometriosis and Hodgkin′s disease.
Physical form
Sterile filtered and then lyophilized with no additives. The protein may appear as a haze or film that is difficult to see at the bottom of the vial.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1 μg/μL. It is recommended that further dilutions be made into buffer containing carrier protein or medium containing serum.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Xiang Zhu et al.
BMC immunology, 14, 24-24 (2013-05-28)
Proton currents are required for optimal respiratory burst in phagocytes. Recently, HVCN1 was identified as the molecule required for the voltage-gated proton channel activity associated with the respiratory burst in neutrophils. Although there are similarities between eosinophils and neutrophils regarding
E P Bowman et al.
The Journal of experimental medicine, 191(8), 1303-1318 (2000-04-19)
Developing B cells undergo dramatic changes in their responses to chemoattractant cytokines (chemokines) and in expression of chemokine receptors. Bone marrow pre-pro-B cells (AA4.1(+)/natural killer 1.1(-) Fraction A cells) and cells capable of generating pro-B colonies in the presence of
Ravindra B Kodali et al.
Arteriosclerosis, thrombosis, and vascular biology, 24(7), 1211-1216 (2004-05-08)
CCL11 (Eotaxin) is a potent eosinophil chemoattractant that is abundant in atheromatous plaques. The major receptor for CCL11 is CCR3, which is found on leukocytes and on some nonleukocytic cells. We sought to determine whether vascular smooth muscle cells (SMCs)
J Elsner et al.
European journal of immunology, 26(8), 1919-1925 (1996-08-01)
Increased numbers of eosinophils are found in parasitic infections, autoimmune diseases and allergic diseases such as allergic asthma. They are activated by distinct cytokines and chemokines leading to the immigration in the inflamed tissue and mediate tissue damage by releasing
E A Garcia-Zepeda et al.
Genomics, 41(3), 471-476 (1997-05-01)
Eotaxin is a CC chemokine that is a specific chemoattractant for eosinophils and is implicated in the pathogenesis of eosinophilic inflammatory diseases, such as asthma. We describe the genomic organization, complete sequence, including 1354 bp 5' of the RNA initiation
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