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Merck
CN

SRP4066

FGF-21 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym(s):

FGF21, FGFL, Fibroblast growth factor 21

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About This Item

NACRES:
NA.32
UNSPSC Code:
12352202
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biological source

human

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

~19.5 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FGF21(26291)

General description

FGF21 (fibroblast growth factor) belongs to FGF superfamily. It is generated by the liver. The gene is mapped to human chromosome 19q13.33.
Recombinant Human FGF-21 produced in Escherichia coli is a single, non-glycosylated polypeptide chain containing 182 amino acids and having a molecular mass of 19.5kDa.

Biochem/physiol Actions

FGF21 (fibroblast growth factor) is a hormonal factor which controls glucose homeostasis and energy metabolism. It exhibits anti-diabetic properties by controlling glucose uptake in peripheral tissues. It also possesses autocrine effects in white adipose tissue. FGF21 is present in milk and is needed for intestinal function in the neonate. It is also involved in bone loss. FGF21 exhibits hepatoprotective properties.

Physical form

Lyopohilized from 10 mM Tris, pH 7.5 plus 100 mM NaCl.

Preparation Note

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/mL, which can be further diluted into other aqueous solutions.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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