SRP4304
NGF-beta from mouse
recombinant, expressed in E. coli, ≥98% (SDS-PAGE)
Synonym(s):
Nerve Growth Factor β, Ngf, Ngfb
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Product Name
NGF-beta from mouse, recombinant, expressed in E. coli, ≥98% (SDS-PAGE)
biological source
mouse
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
lyophilized
potency
0.2 ng/mL ED50
mol wt
~13.4 kDa
packaging
pkg of 20 μg
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Ngf(18049)
Biochem/physiol Actions
Nerve growth factor-β (NGF-β) is a potent neurotrophic factor that supports the growth and survivability of nerve and/or glial cells. It brings pro-survival effects with the help of receptor tyrosine kinase TrkA. NGF-β is associated with diabetic neuropathy and ischemic heart disease. It is also involved in airway nerve system. NGF-β is also responsible for the pain which is linked with osteoarthritis (OA). It is involved in liver fibrosis, carcinogenesis, angiogenesis and cholangiocyte proliferation.
General description
Nerve growth factor-β (NGF-β) belongs to the neurotrophin family. The active form of human NGF-β is a homodimer, non-glycosylated chain.
Physical form
Lyophilized without any additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL containing 1% HSA or BSA. The solution can be diluted into other aqueous buffers and stored at 4°C for 2-7 days or store at –20°C for future use.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Up-regulation of nerve growth factor in cholestatic livers and its hepatoprotective role against oxidative stress.
Tsai MS
PLoS ONE, 9, e112113-e112113 (2014)
Expression of nerve growth factor and vascular endothelial growth factor in the inferior alveolar nerve after distraction osteogenesis.
Park BW
International Journal of Oral and Maxillofacial Surgery, 35, 624-630 (2006)
The Effects of Nerve Growth Factor on Nicotinic Synaptic Transmission in Mouse Airway Parasympathetic Neurons.
Weigand LA
American Journal of Respiratory Cell and Molecular Biology, 53, 443-449 (2015)
Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner.
Mnich K
Cell Death & Disease, 5, e1202-e1202 (2014)
Nerve growth factor rescues diabetic mice heart after ischemia/reperfusion injury via up-regulation of the TRPV1 receptor.
Zheng LR
The Journal of Diabetic Complications, 29, 323-328 (2015)
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