SRP4304
NGF-beta from mouse
recombinant, expressed in E. coli, ≥98% (SDS-PAGE)
Synonym(s):
Nerve Growth Factor β, Ngf, Ngfb
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Product Name
NGF-beta from mouse, recombinant, expressed in E. coli, ≥98% (SDS-PAGE)
biological source
mouse
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
lyophilized
potency
0.2 ng/mL ED50
mol wt
~13.4 kDa
packaging
pkg of 20 μg
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Ngf(18049)
Biochem/physiol Actions
Nerve growth factor-β (NGF-β) is a potent neurotrophic factor that supports the growth and survivability of nerve and/or glial cells. It brings pro-survival effects with the help of receptor tyrosine kinase TrkA. NGF-β is associated with diabetic neuropathy and ischemic heart disease. It is also involved in airway nerve system. NGF-β is also responsible for the pain which is linked with osteoarthritis (OA). It is involved in liver fibrosis, carcinogenesis, angiogenesis and cholangiocyte proliferation.
General description
Nerve growth factor-β (NGF-β) belongs to the neurotrophin family. The active form of human NGF-β is a homodimer, non-glycosylated chain.
Physical form
Lyophilized without any additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL containing 1% HSA or BSA. The solution can be diluted into other aqueous buffers and stored at 4°C for 2-7 days or store at –20°C for future use.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Expression of nerve growth factor and vascular endothelial growth factor in the inferior alveolar nerve after distraction osteogenesis.
Park BW
International Journal of Oral and Maxillofacial Surgery, 35, 624-630 (2006)
The Effects of Nerve Growth Factor on Nicotinic Synaptic Transmission in Mouse Airway Parasympathetic Neurons.
Weigand LA
American Journal of Respiratory Cell and Molecular Biology, 53, 443-449 (2015)
Up-regulation of nerve growth factor in cholestatic livers and its hepatoprotective role against oxidative stress.
Tsai MS
PLoS ONE, 9, e112113-e112113 (2014)
Induction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain.
Arthritis Research & Therapy, 16, R16-R16 (2014)
Nerve growth factor rescues diabetic mice heart after ischemia/reperfusion injury via up-regulation of the TRPV1 receptor.
Zheng LR
The Journal of Diabetic Complications, 29, 323-328 (2015)
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