SRP4364
VEGF165 from mouse
recombinant, expressed in E. coli
Synonym(s):
MGC70609, VEGF, VEGF-A, VPF, Vascular endothelial growth factor A, Vascular permeability factor
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
biological source
mouse
recombinant
expressed in E. coli
assay
≥98%
form
lyophilized
potency
1.0-5 ng/mL
mol wt
~39.0 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Vegfa(22339)
General description
VEGF (vascular endothelial growth factor) is a homodimeric protein secreted by a variety of vascularized tissues. It is expressed embryonically in mice, in the lung mesenchyme and epithelium. It belongs to the group of vascular endothelium-specific growth factors. Mouse VEGF is a 39kDa homodimeric protein consisting of two 165 amino acid polypeptide chains.
Biochem/physiol Actions
VEGF (vascular endothelial growth factor) stimulates endothelial cell growth, angiogenesis, vasculogenesis and capillary permeability. It has a role in the differentiation of mesenchymal stem cells into osteoblasts and adipocytes. Disruption of this gene in mice has been associated with vascular abnormalities.
Physical form
Lyophilized without any additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Vascular-specific growth factors and blood vessel formation.
Yancopoulos GD
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Sequestration of Vascular Endothelial Growth Factor (VEGF) Induces Late Restrictive Lung Disease.
Wieck MM
PLoS ONE, 11(2), e0148323-e0148323 (2016)
Vascular Endothelial Growth Factor (VEGF) Bioavailability Regulates Angiogenesis and Intestinal Stem and Progenitor Cell Proliferation during Postnatal Small Intestinal Development.
Schlieve CR
PLoS ONE, 11(3), e0151396-e0151396 (2016)
Louisa Mezache et al.
Scientific reports, 10(1), 20463-20463 (2020-11-26)
Atrial fibrillation (AF) is the most common arrhythmia and is associated with inflammation. AF patients have elevated levels of inflammatory cytokines known to promote vascular leak, such as vascular endothelial growth factor A (VEGF). However, the contribution of vascular leak
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