SRP4505
FABP5 human
recombinant, expressed in E. coli
Synonym(s):
E-FABP, Epidermal-type fatty acid-binding protein, Fatty acid-binding protein 5, Fatty acid-binding protein epidermal, Psoriasis-associated fatty acid-binding protein homolog
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
≥98% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
~16 kDa
biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
lyophilized
mol wt
~16 kDa
packaging
pkg of 100 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... FABP5(2171)
General description
FABPs (fatty acid-binding proteins) are small 14-15kDa intracellular cytosolic proteins. They are needed for the transport of lipids to specific areas in cells. The FABP5 gene is mapped to human chromosome 8q21.
Biochem/physiol Actions
FABP5 (fatty acid-binding protein 5) is involved in the pathogenesis of metabolic diseases. Absence of FABP-4 and -5 in mice protects them against diet-induced obesity, insulin resistance, type 2 diabetes, atherosclerosis and fatty liver disease. FABP5 is also associated with bladder, pancreas, prostate, breast cancers and glioblastoma.
Physical form
Sterile filtered and Lyophilized without additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Farzad S Forootan et al.
Oncotarget, 7(8), 9322-9339 (2016-01-28)
In previous work, it is suggested that the excessive amount of fatty acids transported by FABP5 may facilitate the malignant progression of prostate cancer cells through a FABP5-PPARγ-VEGF signal transduction axis to increase angiogenesis. To further functionally characterise the FABP5-PPARγ-VEGF
Fatty acid activated PPAR? promotes tumorigenicity of prostate cancer cells by up regulating VEGF via PPAR responsive elements of the promoter.
Forootan FS, et al.
Oncotarget, 7, 9322-9322 (2016)
A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting.
Syamsunarno MR, et al.
PLoS ONE, 8, e79386-e79386 (2013)
A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis.
Liu RZ, et al.
Genomics, 92, 436-436 (2008)
Long Pan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 106, 68-76 (2018-06-30)
Tumor angiogenesis is an essential process for facilitating tumor growth and metastasis. Fatty acid binding protein 5(FABP5)is highly expressed in hepatocellular carcinoma (HCC). Thus, we investigated the role of FABP5 in tumor angiogenesis during HCC development. In this study, the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SRP4505-100UG | 04061837226687 |
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