SRP4542
FGF-19 human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym(s):
FGF19, FGFJ, fibroblast growth factor 19
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
biological source
human
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
lyophilized
potency
50-200 ng/mL
mol wt
~21.8 kDa
packaging
pkg of 25 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... FGF19(9965)
General description
Fibroblast growth factor-19 (FGF-19) is an ileum-derived polypeptide hormone and a high affinity heparin-dependent ligand for fibroblast growth factor receptor 4 (FGFR4). It is part of the hormone-like FGF family. The gene encoding FGF-19 is localized on human chromosome 11q13.3. Recombinant human FGF-19 is a 21.8kDa protein containing 195 amino acid residues.
Biochem/physiol Actions
Fibroblast growth factor-19 (FGF-19) is involved in the gut-liver signaling pathway and modulation of bile acid synthesis. Once secreted, it binds to the hepatic fibroblast growth factor receptor 4 (FGFR4)/Klotho-β cell-surface receptor complex and activates it. FGF-19 promotes glycogen synthesis, protein synthesis and lipid metabolism.
Physical form
Lyophilized from 5 mM Tris, pH 7.6 plus 75 mM NaCl. The protein may appear as a haze or film, which you may not see at the bottom of the vial.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1 to 1.0 μg/μL. This solution can then be diluted into other aqueous buffers.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening.
Sawey ET
Cancer Cell, 19(3), 347-358 (2011)
Targeting fibroblast growth factor 19 in liver disease: a potential biomarker and therapeutic target.
Liu WY
Expert Opinion on Therapeutic Targets, 19(5), 675-685 (2015)
Expression of hepatic Fibroblast Growth Factor 19 is enhanced in Primary Biliary Cirrhosis and correlates with severity of the disease.
Wunsch E
Scientific Reports, 5, 13462-13462 (2015)
Articles
Fibroblast growth factors in cell culture and various growth factors for your research
用于细胞培养的成纤维细胞生长因子，以及用于您的研究的各类生长因子
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