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SRP4561

Sigma-Aldrich

Resistin from rat

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym(s):

ADSF, Adipose tissue-specific secretory factor, C/EBP-ε-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-α-like 2, Cysteine-rich secreted protein FIZZ3, RSTN

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About This Item

MDL number:
MFCD03792461
UNSPSC Code:
12352200
NACRES:
NA.32

Key Documents

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biological source

rat

recombinant

expressed in E. coli

Assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

~11.9 kDa

packaging

pkg of 25 μg

impurities

endotoxin, tested

NCBI accession no.

NP_653342

UniProt accession no.

Q8CJE0

shipped in

wet ice

storage temp.

−20°C

Gene Information

rat ... Retn(246250)

General description

Resistin is a new member to of the family of adipocyte-secreted proteins. The biological functions of resistin, as well as its molecular target, are largely unknown. Whether it promotes or antagonizes insulin action is still unclear. Recombinant rat Resistin is an 11.9 kDa protein consisting of 94 amino acid residues and 16 additional amino acids residues-His Tag.
Resistin is an adipocytokine secreted by fat tissues and is localized to pancreatic α-cells in rat.

Application

Resistin from rat has been used to study the effect of resistin on gonadotropins and local ovarian hormone-induced steroidogenesis.

Biochem/physiol Actions

Resistin mediates energy homeostasis and inflammation process. Upregulation of resistin is observed in obesity. It is also known to increase blood glucose level and might promote insulin resistance. Thus, it might influence type 2 diabetes. Resistin might be linked to insulin resistance mediated myocardial infarction (MI). In rats, overexpression of resistin is observed in myocardial infarction and cardiac dysfunction.

Physical form

Lyophilized from 20 mM Tris, pH 8.0.

Preparation Note

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
60761
60461

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Regulatory role of gonadotropins and local factors produced by ovarian follicles on in vitro resistin expression and action on porcine follicular steroidogenesis
Rak A, et al.
Biology of Reproduction, 92(6), 142-141 (2015)
Maha M Sabry et al.
Archives of physiology and biochemistry, 126(5), 389-398 (2019-01-08)
Obesity and atherosclerosis are inflammatory states involving variable metabolic signals. The adipokine resistin is implicated in adipose tissue dysfunction and is modulated by PPARγ. In this study, resistin and PPARγ role is investigated in the development of CVS disease. Forty-eight
JingJing Shang et al.
iScience, 26(7), 107025-107025 (2023-06-30)
Osteogenic differentiation (OD) of bone marrow mesenchymal stem cells (BMSCs) contributes significantly to the regeneration of bone defects. Resistin, an adipose tissue-specific secretory factor, has been shown to involve many different functions, including metabolism, inflammation, cancer, and bone remodeling. However
Resistin is produced by rat pancreatic islets and regulates insulin and glucagon in vitro secretion
Sassek M, et al.
Islets, 8(6), 177-185 (2016)
Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signaling in infarcted rats
Lee TM, et al.
Bioscience Reports, BSR20150139-BSR20150139 (2016)
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