SRP4642
VEGF-B human
recombinant, expressed in E. coli
Synonym(s):
VEGFB, Vascular Endothelial Growth Factor-B
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
biological source
human
recombinant
expressed in E. coli
Assay
≥98% (SDS-PAGE)
form
lyophilized
potency
0.5-5.0 μg/mL
mol wt
~19.63 kDa
packaging
pkg of 20 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... VEGFB(7423)
General description
Vascular endothelial growth factor B (VEGF-B), a member of the VEGF family, is a potent growth and angiogenic cytokine. VEGF-B is expressed in all tissues except the liver. It forms cell surface-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a "cysteine knot" like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. The gene encoding this protein is localized on human chromosome 11q13 and contains seven exons. Recombinant human VEGF-B is a 38kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.
Biochem/physiol Actions
Vascular endothelial growth factor B (VEGF-B) promotes DNA synthesis in endothelial cells, regulates angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. It has a role in coronary vessel growth and cardiac hypertrophy, which might provide protection to heart against ischemic damage and heart failure. VEGF-B is also involved in neuroprotection. The protein might have a role in metabolic functions since it is highly expressed in tissues with highly active energy metabolism.
Physical form
Lyophilized without any additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Roles of Vascular Endothelial Growth Factor in Amyotrophic Lateral Sclerosis
Ana Catarina
BioMed Research International, 947513-947513 (2014)
Vascular endothelial growth factor and angiogenesis.
Hoeben A et al
Pharmacological Reviews, 56(4), 549-580 (2004)
Vascular endothelial growth factor-B in physiology and disease.
Bry M et al
Physiological Reviews, 94(3), 779-794 (2014)
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