SRP4928
Lipocalin-2 human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Synonym(s):
25 kDa α-2-microglobulin-related subunit of MMP-9, Lipocalin-2, NGAL, Neutrophil gelatinase-associated lipocalin, Oncogene 24p3, p25
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Product Name
Lipocalin-2 human, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
biological source
human
recombinant
expressed in E. coli
assay
≥95% (HPLC)
≥95% (SDS-PAGE)
form
lyophilized
mol wt
~20 kDa
packaging
pkg of 50 μg
technique(s)
activity assay: suitable
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... LCN2(3934)
Application
LCN2 (lipocalin 2)-human has been used in the cell proliferation assay.It has also been used in conductometric immunoassay in renal carcinoma cells.
Biochem/physiol Actions
LCN2 (lipocalin 2) potentially connects obesity and its related adipose inflammation. LCN2 has also been implicated in a variety of processes including cell differentiation, tumorigenesis, and apoptosis. It is an early marker of acute kidney injury, cardiovascular diseases, lupus nephritis, and intestinal inflammation. LCN2 is upregulated in humans with heart failure. It can associate with MMP9 (matrix metalloproteinase-9) and controls its stability. Changes in the expression of LCN2 are associated with many cancers, including breast, colorectal, pancreatic, ovarian, gastric, thyroid, ovarian, bladder, and kidney cancers.LCN2 acts as a pleiotropicmolecule and plays a role in several pathophysiological and physiologicalactivities including immune response, inflammation, metabolic homeostasis, andinfection.
General description
Research area: Cell signaling. The gene LCN2 (lipocalin 2) is mapped to human chromosome 9q34. LCN2, a secreted glycoprotein, is an adipokine. It is expressed by many cells, such as respiratory and intestinal epithelial cells, endothelial cells, renal tubular cells, and cardiomyocytes. LCN2 belongs to the lipocalin family. LCN2 consists of the lipid binding domain that binds to small hydrophobic molecules and the ligand binding cavity that binds to bacterial and mammalian proteins called siderophores.
Physical form
Lyophilized with no additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration 0.1-1 mg/mL. The solution can then be further diluted to other aqueous solutions.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Epigenetic induction of epithelial to mesenchymal transition by LCN2 mediates metastasis and tumorigenesis, which is abrogated by NF-?B inhibitor BRM270 in a xenograft model of lung adenocarcinoma.
International Journal of Oncology, 48, 84-98 (2016)
Gordon P Otto et al.
PloS one, 10(4), e0124429-e0124429 (2015-04-22)
Acute kidney injury (AKI) during sepsis is common and underestimated. Plasma neutrophil gelatinase-associated lipocalin (plasma-NGAL) is discussed as new biomarker for AKI diagnosis, but during inflammation its function and diagnostic impact remain unclear. The association between plasma-NGAL and inflammatory markers
Vanessa Abella et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 20(8), 565-571 (2015-12-17)
Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to
Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans.
Catalan V
Journal of Molecular Medicine, 87, 803-813 (2009)
Guoliang Wang et al.
International journal of biological sciences, 10(7), 798-806 (2014-08-01)
A key feature of pulmonary hypertension (PH) is the remodeling of small pulmonary arteries due to abnormal pulmonary artery smooth muscle cell (PASMC) proliferation and resistance to apoptosis. However, the cellular mechanisms underlying how PASMCs in the pathological condition of
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